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Case Reports
. 2024 Jan 9:45:123-127.
doi: 10.1016/j.jdcr.2023.12.005. eCollection 2024 Mar.

Cronkhite-Canada syndrome: An atypical presentation with subungual hyperkeratosis

Affiliations
Case Reports

Cronkhite-Canada syndrome: An atypical presentation with subungual hyperkeratosis

Peerada Sermswan et al. JAAD Case Rep. .
No abstract available

Keywords: Cronkhite-Canada syndrome; acquired gastrointestinal polyposis; acrofacial lentigines; juvenile hamartoma; nonhereditary polyposis; onychodystrophy.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Cutaneous features of Cronkhite-Canada syndrome. Multiple brownishmacules on the palms (A, B), perioral area (C), and soles (D).
Fig 2
Fig 2
Nail features of Cronkhite-Canada syndrome. Marked subungual hyperkeratosis and onychorrhexis of fingernails (A) and toenails (B).
Fig 3
Fig 3
Esophagoduodenoscopy of Cronkhite-Canada syndrome. Colonic inflammatory polyps (A). Hematoxylin and eosin-stained histopathological findings of the polyp showed juvenile hamartomatous polyp with cystic dilation of glands and infiltration of inflammatory cells including eosinophils (B).
Fig 4
Fig 4
Cutaneous features improvement of Cronkhite-Canada syndrome. Proximal nails appeared normal (A). The brownishmacules perioral area (B) and palms (C) turned lighter.

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References

    1. Cronkhite L.W., Jr., Canada W.J. Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia. N Engl J Med. 1955;252(24):1011–1015. doi: 10.1056/NEJM195506162522401. - DOI - PubMed
    1. Watanabe C., Komoto S., Tomita K., et al. Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey. J Gastroenterol. 2016;51(4):327–336. doi: 10.1007/s00535-015-1107-7. - DOI - PMC - PubMed
    1. Li Z.D., Rong L., He Y.J., et al. Exome analysis for Cronkhite-Canada syndrome: a case report. World J Clin Cases. 2022;10(24):8634–8640. doi: 10.12998/wjcc.v10.i24.8634. - DOI - PMC - PubMed
    1. Sweetser S., Ahlquist D.A., Osborn N.K., et al. Clinicopathologic features and treatment outcomes in Cronkhite-Canada syndrome: support for autoimmunity. Dig Dis Sci. 2012;57(2):496–502. doi: 10.1007/s10620-011-1874-9. - DOI - PubMed
    1. She Q., Jiang J.X., Si X.M., Tian X.Y., Shi R.H., Zhang G.X. A severe course of Cronkhite-Canada syndrome and the review of clinical features and therapy in 49 Chinese patients. Turk J Gastroenterol. 2013;24(3):277–285. doi: 10.4318/tjg.2013.0527. - DOI - PubMed

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