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. 2024 Feb 16;16(2):55-63.
doi: 10.4253/wjge.v16.i2.55.

Association between triglyceride-glucose index and colorectal polyps: A retrospective cross-sectional study

Ya-Jie Teng  1 , Ying-Xue Yang  1 , Jing-Jing Yang  1 , Qiu-Yan Lu  1 , Jia-Yi Shi  1 , Jian-Hao Xu  2 , Jie Bao  1 , Qing-Hua Wang  3
Affiliations

Association between triglyceride-glucose index and colorectal polyps: A retrospective cross-sectional study

Ya-Jie Teng et al. World J Gastrointest Endosc. .

Retraction in

Abstract

Background: Colorectal polyps (CPs) are frequently occurring abnormal growths in the colorectum, and are a primary precursor of colorectal cancer (CRC). The triglyceride-glucose (TyG) index is a novel marker that assesses metabolic health and insulin resistance, and has been linked to gastrointestinal cancers.

Aim: To investigate the potential association between the TyG index and CPs, as the relation between them has not been documented.

Methods: A total of 2537 persons undergoing a routine health physical examination and colonoscopy at The First People's Hospital of Kunshan, Jiangsu Province, China, between January 2020 and December 2022 were included in this retrospective cross-sectional study. After excluding individuals who did not meet the eligibility criteria, descriptive statistics were used to compare characteristics between patients with and without CPs. Logistic regression analyses were conducted to determine the associations between the TyG index and the prevalence of CPs. The TyG index was calculated using the following formula: Ln [triglyceride (mg/dL) × glucose (mg/dL)/2]. The presence and types of CPs was determined based on data from colonoscopy reports and pathology reports.

Results: A nonlinear relation between the TyG index and the prevalence of CPs was identified, and exhibited a curvilinear pattern with a cut-off point of 2.31. A significant association was observed before the turning point, with an odds ratio (95% confidence interval) of 1.70 (1.40, 2.06), P < 0.0001. However, the association between the TyG index and CPs was not significant after the cut-off point, with an odds ratio (95% confidence interval) of 0.57 (0.27, 1.23), P = 0.1521.

Conclusion: Our study revealed a curvilinear association between the TyG index and CPs in Chinese individuals, suggesting its potential utility in developing colonoscopy screening strategies for preventing CRC.

Keywords: Colorectal cancer; Colorectal polyps; Cross-sectional study; Insulin resistance; Triglyceride-glucose index.

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Conflict of interest statement

Conflict-of-interest statement: The authors declared no conflict-of-interest.

Figures

Figure 1
Figure 1
Flow diagram of patient inclusion and exclusion. CRC: Colorectal cancer.
Figure 2
Figure 2
The association between triglyceride-glucose index and colorectal polyps. Age, sex, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were adjusted.
See this image and copyright information in PMC

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