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Case Reports
. 2024 Feb 26;12(6):1190-1195.
doi: 10.12998/wjcc.v12.i6.1190.

Management of retroperitoneal high-grade serous carcinoma of unknown origin: A case report

Wen-Lin Hsieh  1 , Dah-Ching Ding  1   2
Affiliations
Case Reports

Management of retroperitoneal high-grade serous carcinoma of unknown origin: A case report

Wen-Lin Hsieh et al. World J Clin Cases. .

Abstract

Background: Retroperitoneal high-grade serous carcinoma (HGSC) of unknown origin is a sporadic tumor that can originate from ovarian cancer. Herein, we report the case of a woman with retroperitoneal HGSC of unknown origin and describe how she was diagnosed and treated.

Case summary: A 71-year-old female presented with the tumor marker CA125 elevated to 1041.9 U/mL upon a regular health examination. Computed tomography revealed retroperitoneal lymph node enlargement. Subsequently, positron emission tomography scanning revealed lesions with increased F-18 fluorodeoxyglucose uptake at the nodes. As a result, she underwent laparoscopic lymph node resection, and pathology revealed metastatic adenocarcinoma with CK7(+), PAX8(+), WT1(+), PR(-), and p53 mutational loss of expression, indicating that the origin may be from the adnexa. The patient was admitted to our ward and underwent laparoscopic staging; however, the pathological results were negative. Under the suspicion of retroperitoneal HGSC of unknown origin, chemotherapy and targeted therapy were initiated. Tumor marker levels decreased after treatment.

Conclusion: We present a case of HGSC of unknown origin managed using retroperitoneal lymphadenectomy, staging surgery, chemotherapy, and targeted therapy.

Keywords: Case report; Chemotherapy; High-grade serous carcinoma; Lymph node; Origin; Retroperitoneum.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Immunohistochemistry of the retroperitoneal high-grade serous carcinoma. The carcinoma was negative for p53 (scale bar = 200 μm), and positive for WT1, PAX8, and CK7 (scale bar = 1 mm).
See this image and copyright information in PMC

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