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Review
. 2024 Feb 21;19(1):20220827.
doi: 10.1515/biol-2022-0827. eCollection 2024.

Current research and evidence gaps on placental development in iron deficiency anemia

Shaoyang Lai  1 , Weiwei Yu  1 , Ying Liu  1 , Yuxin Yang  1 , Xueqin Zhang  1
Affiliations
Review

Current research and evidence gaps on placental development in iron deficiency anemia

Shaoyang Lai et al. Open Life Sci. .

Abstract

Studying the effects of maternal iron deficiency anemia (IDA) is complex owing to its diverse causes, each independently impacting the placenta and fetus. Simple treatment with iron supplements does not always resolve the anemia. Therefore, delving into how IDA alters placental development at a molecular level is crucial to further optimize treatment. This review addresses the effects of IDA on placental structures and functions, including changes in oxygen levels, blood vessels, and the immune system. Profound understanding of physiological characteristics and regulatory mechanisms of placental development is key to explain the mechanisms of abnormal placental development in pregnancy-associated disorders. In turn, future strategies for the prevention and treatment of pregnancy complications involving the placenta can be devised. These studies are significant for improving human reproductive health, enhancing sociodemographic qualities, and even lifelong wellbeing, a focal point in future placental research.

Keywords: iron deficiency; maternal anemia; placental development; placental-associated disorders.

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Conflict of interest statement

Conflict of interest: Authors state no conflict of interest.

Figures

Figure 1
Figure 1
The latest theories of the placental development.
Figure 2
Figure 2
Proposed mechanisms by which IDA may influence the placental development.
See this image and copyright information in PMC

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References

    1. Raut AK, Hiwale KM. Iron deficiency anemia in pregnancy. Cureus. 2022;14(9):e28918. 10.7759/cureus.28918. - DOI - PMC - PubMed
    1. Ajepe AA, Okunade KS, Sekumade AI, Daramola ES, Beke MO, Ijasan O, et al. Prevalence and foetomaternal effects of iron deficiency anaemia among pregnant women in Lagos, Nigeria. PLoS One. 2020;15(1):e227965. 10.1371/journal.pone.0227965. - DOI - PMC - PubMed
    1. Wu Y, Ye H, Liu J, Ma Q, Yuan Y, Pang Q, et al. Prevalence of anemia and sociodemographic characteristics among pregnant and non-pregnant women in southwest China: A longitudinal observational study. BMC Pregnancy Childbirth. 2020;20(1):535. 10.1186/s12884-020-03222-1. - DOI - PMC - PubMed
    1. Dewangga R, Winston K. The role of iron supplementation in reducing all-cause mortality of heart failure patients with iron deficiency: A systematic review and metaanalysis. Eur Heart J. 2021;(Supplement_1):Supplement_1. 10.1093/eurheartj/ehab724.0918. - DOI
    1. Freitas M. Efficacy of intravenous iron therapy in iron-deficient patients with heart failure: An updated systematic review and meta-analysis. Eur Heart J. 2023;(Supplement_2):Supplement_2. 10.1093/eurheartj/ehad655.873. - DOI

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