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Review
. 2024 Jun 1;67(2):411-417.
doi: 10.1097/GRF.0000000000000857. Epub 2024 Mar 11.

Clinical Trials That Have Changed Obstetric Practice: The Chronic Hypertension and Pregnancy (CHAP) Trial

Ayodeji A Sanusi, Rachel G Sinkey, Alan T N Tita
Review

Clinical Trials That Have Changed Obstetric Practice: The Chronic Hypertension and Pregnancy (CHAP) Trial

Ayodeji A Sanusi et al. Clin Obstet Gynecol. .

Abstract

We describe the evolution of treatment recommendations for chronic hypertension (CHTN) in pregnancy, the CHTN and pregnancy (CHAP) trial, and its impact on obstetric practice. The US multicenter CHAP trial showed that antihypertensive treatment for mild CHTN in pregnancy [blood pressures (BP)<160/105 mm Hg] to goal<140/90 mm Hg, primarily with labetalol or nifedipine compared with no treatment unless BP were severe reduced the composite risk of superimposed severe preeclampsia, indicated preterm birth <35 weeks, placental abruption, and fetal/neonatal death. As a result of this trial, professional societies in the United States recommended treatment of patients with CHTN in pregnancy to BP goal<140/90 mm Hg.

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Figures

Figure 1:
Figure 1:. Outcomes of Active Treatment (vs. Usual Care) in Patients With Mild Chronic Hypertension in Pregnancy
Data are proportion/percentage
Figure 2:
Figure 2:. Incidence of Small for Gestational Age With Active Treatment (vs. Usual Care) of Mild Chronic Hypertension in Pregnancy
Data are proportion/percentage
See this image and copyright information in PMC

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