Improving T cell killing and understanding senescence: Possible roles for TP53 in cancer immunotherapy
- PMID: 38466858
- PMCID: PMC10962976
- DOI: 10.1073/pnas.2402533121
Improving T cell killing and understanding senescence: Possible roles for TP53 in cancer immunotherapy
Conflict of interest statement
Competing interests statement:A.J.L. is a consultant for Chugai Pharmaceutical company. He is a founder, board member and consultant at PMV Pharma, which produces small molecules that reactivate p53 mutant proteins and produce wild type proteins. He is a board member of GeneCentric a cancer RNA diagnostic company. And he consults for ROME (autoimmunity), and WCG (an IRB company).
Comment on
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Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α.Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2317735121. doi: 10.1073/pnas.2317735121. Epub 2024 Feb 26. Proc Natl Acad Sci U S A. 2024. PMID: 38408246 Free PMC article.
References
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- Levine A. J., P53 and the immune response: 40 years of Exploration—a plan for the future. Review in special issue "p53 in Cancer and beyond-40 Years after Its Discovery". Guest Editors: Candeias M., Marco M., Ohki R., Int. J. Mol. Sci. 21, pii: E541 (2020), 10.3390/ijms21020541, PMCID: PMC7013403 PMID: 31952115. - DOI - PMC - PubMed
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