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. 2024:1444:67-82.
doi: 10.1007/978-981-99-9781-7_5.

Regulatory T Cells for Control of Autoimmunity

Ryoji Kawakami  1   2 , Shimon Sakaguchi  3   4
Affiliations

Regulatory T Cells for Control of Autoimmunity

Ryoji Kawakami et al. Adv Exp Med Biol. 2024.

Abstract

Regulatory T (Treg) cells, which specifically express the master transcription factor FoxP3, are indispensable for the maintenance of immunological self-tolerance and homeostasis. Their functional or numerical anomalies can be causative of autoimmune and other inflammatory diseases. Recent advances in the research of the cellular and molecular basis of how Treg cells develop, exert suppression, and maintain their function have enabled devising various ways for controlling physiological and pathological immune responses by targeting Treg cells. It is now envisaged that Treg cells as a "living drug" are able to achieve antigen-specific immune suppression of various immune responses and reestablish immunological self-tolerance in the clinic.

Keywords: Adoptive cell therapy; Autoimmunity; CTLA-4; Foxp3; IL-2; Immune tolerance; Regulatory T cells.

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