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. 2024 Jul;31(7):739-746.
doi: 10.1111/iju.15451. Epub 2024 Mar 12.

Utility of positive core number on MRI-ultrasound fusion targeted biopsy in combination with PI-RADS scores for predicting unexpected extracapsular extension of clinically localized prostate cancer

Masaki Kobayashi  1 , Yoh Matsuoka  1   2 , Sho Uehara  1 , Hiroshi Tanaka  3 , Motohiro Fujiwara  1 , Yuki Nakamura  1 , Yudai Ishikawa  1 , Shohei Fukuda  1 , Yuma Waseda  1 , Hajime Tanaka  1 , Soichiro Yoshida  1 , Yasuhisa Fujii  1
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Utility of positive core number on MRI-ultrasound fusion targeted biopsy in combination with PI-RADS scores for predicting unexpected extracapsular extension of clinically localized prostate cancer

Masaki Kobayashi et al. Int J Urol. 2024 Jul.

Abstract

Objectives: To evaluate the utility of magnetic resonance imaging (MRI) and MRI-ultrasound fusion targeted biopsy (TB) for predicting unexpected extracapsular extension (ECE) in clinically localized prostate cancer (CLPC).

Methods: This study enrolled 89 prostate cancer patients with one or more lesions showing a Prostate Imaging-Reporting and Data System (PI-RADS) score ≥3 but without morphological abnormality in the prostatic capsule on pre-biopsy MRI. All patients underwent TB and systematic biopsy followed by radical prostatectomy (RP). Each lesion was examined by 3-core TB, taking cores from each third of the lesion. The preoperative variables predictive of ECE were explored by referring to RP specimens in the lesion-based analysis.

Results: Overall, 186 lesions, including 81 (43.5%), 73 (39.2%), and 32 (17.2%) with PI-RADS 3, 4, and 5, respectively, were analyzed. One hundred and twenty-two lesions (65.6%) were diagnosed as cancer on TB, and ECE was identified in 33 (17.7%) on the RP specimens. The positive TB core number was ≤2 in 129 lesions (69.4%) and three in 57 lesions (30.6%). On the multivariate analysis, PI-RADS ≥4 (p = 0.049, odds ratio [OR] = 2.39) and three positive cores on TB (p = 0.005, OR = 3.07) were independent predictors of ECE. Lesions with PI-RADS ≥4 and a positive TB core number of 3 had a significantly higher rate of ECE than those with PI-RADS 3 and a positive TB core number ≤2 (37.5% vs. 7.8%, p < 0.001).

Conclusions: Positive TB core number in combination with PI-RADS scores is helpful to predict unexpected ECE in CLPC.

Keywords: MRI‐ultrasound fusion targeted prostate biopsy; PI‐RADS scores; extracapsular extension.

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