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. 2023 Nov 5;101(11):839-844.

Psychiatric disturbances in idiopathic epilepsy

Saloua Mrabet  1   2 , Syrine Belguith  1 , Imen Kacem  1   2 , Yosra Zgueb  2   3 , Rim Jenhani  1 , Uta Ouali  2   3 , Amina Nasri  1   3 , Istabrak Abdelkefi  1 , Mouna Ben Djebara  1   2 , Rabaa Jomli  2   3 , Amina Gargouri Berrechid  1   3 , Riadh Gouider  1   3
Affiliations

Psychiatric disturbances in idiopathic epilepsy

Saloua Mrabet et al. Tunis Med. .

Abstract

Introduction: The relationship between epilepsy and psychiatric disorders has been highlighted for a long time. Idiopathic epilepsy is known to have a benign course in most cases. However, the association of psychiatric disturbances could worsen the disease outcome.

Aim: To study the frequency of psychiatric symptoms in patients with idiopathic epilepsy, and to assess the determinant factors in the patient group with these manifestations.

Methods: In one-year prospective study, consecutive patients diagnosed with idiopathic epilepsy were included. Those with a known psychiatric follow-up or with post ictal psychiatric disturbances were excluded. Psychiatric symptoms were evaluated with the Neurological Disorders Depression Inventory for Epilepsy, the Generalized Anxiety Disorder - 7 and the Neuropsychiatric Inventory Scale. Demographic and clinical data were collected and analyzed.

Results: Among 101 consecutive patients with idiopathic epilepsy, psychiatric symptoms were diagnosed in 61% of them. Anxiety (36.6%), psychotic features (21%) and depression (15.8 %) were the most commonly found psychiatric manifestations. Female gender (p < 10-3) and longer duration of epilepsy (p = 0.046) were significantly associated with occurrence of psychiatric disturbances. Patients under Carbamazepine and Valproic acid showed a lower frequency of depression (respectively p = 0.018 and p = 0.003).

Conclusions: Occurrence of psychiatric disturbances was frequent in idiopathic epilepsy, with psychotic manifestations and anxiety being the most common of them. Female gender and long disease course were the main determining factors of psychiatric manifestations and should be considered in management of idiopathic epilepsy.

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Figures

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Figure 1. Prescribed antiseizure medications in our cohort (%)
See this image and copyright information in PMC

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