Neglected Tropical Diseases: A Comprehensive Review
- PMID: 38468991
- PMCID: PMC10925483
- DOI: 10.7759/cureus.53933
Neglected Tropical Diseases: A Comprehensive Review
Abstract
Neglected tropical diseases (NTDs) are a group of diseases caused by diverse organisms, affecting millions of people in tropical and subtropical conditions. NTDs are more prevalent among people who live in poverty, without access to clean water, adequate sanitation, and quality health care. Most NTDs are chronic conditions and are potentially disablers than killers, leaving behind a trail of social consequences. Controlling NTDs has become complicated due to limited resources and are frequently ignored by global funding agencies. India experiences a significant burden of global NTDs. The paradox is that NTDs are preventable and treatable at an affordable cost. It then makes no sense as to why we co-exist with such diseases. The World Health Organization (WHO) has donned the leadership role of eliminating, eradicating, and controlling global NTDs. The WHO published a roadmap delineating a plan of action, which was being reviewed periodically. This led to substantive progress in tackling the NTDs. However, many challenges still exist to controlling and preventing NTDs. India has achieved significant progress towards NTD control and elimination by implementing the WHO strategies and action plans. This was evident by an increase in research and funding in this direction. The number of new drugs, vaccines, and investigative tools available and those in the pipeline is testimony to their efforts. Focusing singly on India's NTD problem would substantially reduce the burden of poverty-related neglected diseases and could dramatically advance the global health agenda. This review highlights the problem of NTDs in the Indian and global perspective.
Keywords: controlling ntds; global perspective; india’s ntd problem; neglected tropical diseases (ntds); proverty-related neglected diseases; who strategies; world health organization (who).
Copyright © 2024, CA et al.
Conflict of interest statement
The authors have declared that no competing interests exist.
Figures



Similar articles
-
Impact of COVID-19 on the neglected tropical diseases: a scoping review.Infect Dis Poverty. 2024 Jul 29;13(1):55. doi: 10.1186/s40249-024-01223-2. Infect Dis Poverty. 2024. PMID: 39075616 Free PMC article.
-
Neglected tropical diseases: an effective global response to local poverty-related disease priorities.Infect Dis Poverty. 2020 Jan 28;9(1):10. doi: 10.1186/s40249-020-0630-9. Infect Dis Poverty. 2020. PMID: 31987053 Free PMC article. Review.
-
Burden of neglected tropical diseases and access to medicine and diagnostics in Ethiopia: a scoping review.Syst Rev. 2023 Aug 14;12(1):140. doi: 10.1186/s13643-023-02302-5. Syst Rev. 2023. PMID: 37580784 Free PMC article.
-
An Investment Case for Ending Neglected Tropical Diseases.In: Holmes KK, Bertozzi S, Bloom BR, Jha P, editors. Major Infectious Diseases. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Nov 3. Chapter 17. In: Holmes KK, Bertozzi S, Bloom BR, Jha P, editors. Major Infectious Diseases. 3rd edition. Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2017 Nov 3. Chapter 17. PMID: 30212103 Free Books & Documents. Review.
-
Water, sanitation and hygiene for accelerating and sustaining progress on neglected tropical diseases: a new Global Strategy 2015-20.Int Health. 2016 Mar;8 Suppl 1(Suppl 1):i19-21. doi: 10.1093/inthealth/ihv073. Int Health. 2016. PMID: 26940305 Free PMC article.
Cited by
-
Attitudes and acceptance of mRNA-based vaccine for neglected tropical diseases: A multi-country study in Asia.Hum Vaccin Immunother. 2025 Dec;21(1):2526231. doi: 10.1080/21645515.2025.2526231. Epub 2025 Jul 1. Hum Vaccin Immunother. 2025. PMID: 40598764 Free PMC article.
-
Policy and Executive Barriers in Preventing and Eradicating Neglected Tropical Diseases: A Systematic Review.Int J Prev Med. 2024 Oct 18;15:49. doi: 10.4103/ijpvm.ijpvm_251_23. eCollection 2024. Int J Prev Med. 2024. PMID: 39539573 Free PMC article. Review.
-
Atypical neonatal cutaneous myiasis: A diagnostic challenge mimicking pustular rash in a resource-limited setting.Clin Case Rep. 2024 Oct 26;12(11):e9528. doi: 10.1002/ccr3.9528. eCollection 2024 Nov. Clin Case Rep. 2024. PMID: 39464809 Free PMC article.
-
Clinical sensitivity and time-to-result of a cascaded pooled testing approach for assessing the prevalence and intensity of Schistosoma haematobium infection.PLoS Negl Trop Dis. 2024 Aug 22;18(8):e0012435. doi: 10.1371/journal.pntd.0012435. eCollection 2024 Aug. PLoS Negl Trop Dis. 2024. PMID: 39173069 Free PMC article.
-
Trypanosoma cruzi has Two Peptidyl-tRNA Hydrolases Showing Different Localization and Function.Acta Parasitol. 2025 Feb 13;70(1):60. doi: 10.1007/s11686-025-00989-1. Acta Parasitol. 2025. PMID: 39945942
References
-
- Neglected tropical diseases. [ Jan; 2024 ]. 2024. https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_1 https://www.who.int/health-topics/neglected-tropical-diseases#tab=tab_1
-
- Neglected tropical diseases: diagnosis, clinical management, treatment and control. Utzinger J, Becker SL, Knopp S, Blum J, Neumayr AL, Keiser J, Hatz CF. Swiss Med Wkly. 2012;142:0. - PubMed
-
- Hotez PJ. Institute of Medicine (US) Forum on Microbial Threats. The Causes and Impacts of Neglected Tropical and Zoonotic Diseases: Opportunities for Integrated Intervention Strategies. Washington, DC: National Academies Press; 2011. The neglected tropical diseases and the neglected infections of poverty: overview of their common features, global disease burden and distribution, new control tools, and prospects for disease elimination; p. 0. - PubMed
Publication types
LinkOut - more resources
Full Text Sources