Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 9:2022:8523747.
doi: 10.1155/2022/8523747. eCollection 2022.

Clinical Characteristics, Treatment, and Visual Prognosis in Pediatric Endophthalmitis: A 232-Case Retrospective Study

Fantao Lv  1 , Haiyan Wang  1 , Dawei Zhang  1 , Shengwei Wu  1
Affiliations

Clinical Characteristics, Treatment, and Visual Prognosis in Pediatric Endophthalmitis: A 232-Case Retrospective Study

Fantao Lv et al. Appl Bionics Biomech. .

Abstract

Objective: In infective endophthalmitis, once the patient's vision is seriously damaged, the damage to children's vision is particularly serious. The main purpose of this study is to investigate the etiology, epidemiology, treatment, and visual prognosis of children's endophthalmitis and to conduct an in-depth analysis. Study Design. This study collected case data from the Beijing Tongren Hospital Capital Medical University in the period from January 1, 2002 to January 1, 2018. The basic conditions for inclusion in the collection range were patients who were less than or equal to 14 years old and had a history of infectious endophthalmitis. A retrospective study and analysis of etiology, epidemiology, treatment, and visual prognosis were performed. Kappa and Chi square test were used for statistical analysis.

Results: A total of 232 cases were collected, with an average age of 6.33 ± 2.89 years (range 8months to 14 years). The most common etiologies were ocular trauma (93.5%) and previous ocular surgery (5.2%). Overall, 81 samples were sent to the microbiology department for direct smear and culture, from which 21 organisms were isolated. 28 cases (39.5%) were culture-positive. The most organism was Gram-positive organisms. In treatment, the proportion of PPV use combined with silicone oil filling had increased gradually in three phases, while the other treatments were almost decreased or nearly similar. The final visual result is 22 (9.5) in 20/200 or better, 65 (28.0) in CF-20/200, 38 (16.4) in hand move (HM), 27 (11.6) in light perception (LP), 21 (9.1) in no light perception (NLP), and 59 (25.4) did not match (NM).

Conclusion: Penetrating ocular trauma is the most common cause of infectious endophthalmitis in children. The detection rate of microorganisms is low and helpless for the treatment. In this study, it was found that despite the aggressive treatments such as antibacterial and vitrectomy, the ultimate improvement in vision was highly undesirable.

PubMed Disclaimer

Conflict of interest statement

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Age's distribution.
Figure 2
Figure 2
Percentage of cases caused by different types of ocular trauma.
Figure 3
Figure 3
General trends of incidence over the past 15 years.
Figure 4
Figure 4
The percentage of the etiology in every-5-year groups.
Figure 5
Figure 5
Trend changes in different periods of the most common etiologies.
Figure 6
Figure 6
Change trend of the operation in every-5-year groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Cao H., Li L., Zhang M., Li H. Epidemiology of pediatric ocular trauma in the Chaoshan Region, China, 2001-2010. PLoS ONE . 2013;8(4, article e60844) doi: 10.1371/journal.pone.0060844. - DOI - PMC - PubMed
    1. Minderhoud J., van Nispen R. M. A., Heijthuijsen A. A. A. M., et al. Epidemiology and aetiology of childhood ocular trauma in the Republic of Suriname. Acta Ophthalmologica . 2016;94(5):479–484. doi: 10.1111/aos.13000. - DOI - PubMed
    1. Weinstein G. S., Mondino B. J., Weinberg R. J., Biglan A. W. Endophthalmitis in a pediatric population. Annals of Ophthalmology . 1979;11(6):935–943. - PubMed
    1. Al-Rashaed S. A., Abu El-Asrar A. M. Exogenous endophthalmitis in pediatric age group. Ocular Immunology and Inflammation . 2006;14(5):285–292. doi: 10.1080/09273940600954323. - DOI - PubMed
    1. Khan S., Athwal L., Zarbin M., Bhagat N. Pediatric infectious endophthalmitis: a review. Journal of Pediatric Ophthalmology and Strabismus . 2014;51(3):140–153. doi: 10.3928/01913913-20140507-01. - DOI - PubMed

LinkOut - more resources