Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May 1;79(5):glae080.
doi: 10.1093/gerona/glae080.

Pain Characteristics and Progression to Sarcopenia in Chinese Middle-Aged and Older Adults: A 4-Year Longitudinal Study

Jintao Chen  1 , Liying Yan  2 , Jingjing Chu  3 , Xinyi Wang  1 , Zherong Xu  1   4
Affiliations

Pain Characteristics and Progression to Sarcopenia in Chinese Middle-Aged and Older Adults: A 4-Year Longitudinal Study

Jintao Chen et al. J Gerontol A Biol Sci Med Sci. .

Abstract

Background: It is imperative for public health to identify the factors that contribute to the progression of sarcopenia among middle-aged and older adults. Our study aimed to investigate the association between pain characteristics and the progression to sarcopenia and its subcomponents among middle-aged and older adults in China.

Methods: We included 5 568 participants from the China Health and Retirement Longitudinal Study. All participants completed assessments for pain characteristics and sarcopenia. Pain assessment included pain status (baseline pain, incident pain, and pain persistence) and pain distribution (single-site pain and multisite pain) using a self-report questionnaire. Diagnosis of sarcopenia followed The Asian Working Group for Sarcopenia 2019 consensus. The odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by logical regression analysis.

Results: Participants who reported baseline pain, multisite pain, pain persistence, or multisite pain persistence were more likely to progress to sarcopenia than those without pain, with ORs of 1.33 (95% CI: 1.08-1.65), 1.44 (95% CI: 1.15-1.80), 1.63 (95% CI: 1.23-2.14), and 1.59 (95% CI: 1.19-2.11), respectively. Even after adjusting for other covariates such as gender, age, residential area, education level, marital status, smoking, alcohol consumption, comorbidities, and falls, these associations remained significant. Additionally, pain persistence and multisite pain persistence were significantly associated with low grip strength and clinically meaningful Short Physical Performance Battery decline, but not with low muscle mass.

Conclusions: Our study showed that pain, especially pain persistence, was closely correlated to the increased risk of progression to sarcopenia in Chinese middle-aged and older adults.

Keywords: CHARLS; Pain characteristics; Sarcopenia.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1.
Figure 1.
Occurrence of sarcopenia in 4 years according to (A) pain status at baseline, (B) change in pain status over time, (C) pain distribution at baseline, and (D) change in pain distribution over time. Chi-square test for trend ** (p < .01).
Figure 2.
Figure 2.
The link between pain characteristics and progression of sarcopenia subcomponents was analyzed by logistic regression models. Adjusted for age, sex, marital status, education level, residence area, hyperglycemia, hypertension, stroke, heart disease, chronic lung disease, asthma, liver disease, emotional and mental disorders, arthritis, malignancies, and falls (Model 4). Each analysis was conducted after excluding participants with the component of sarcopenia at baseline. CI = confidence interval; OR = odds ratio.
See this image and copyright information in PMC

References

    1. Keller K, Engelhardt M.. Strength and muscle mass loss with aging process. Age and strength loss. Muscles Ligaments Tendons J. 2013;3(4):346–350. - PMC - PubMed
    1. Beaudart C, Rizzoli R, Bruyère O, Reginster JY, Biver E.. Sarcopenia: Burden and challenges for public health. Arch Public Health. 2014;72(1):45. 10.1186/2049-3258-72-45 - DOI - PMC - PubMed
    1. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. ; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31. 10.1093/ageing/afy169 - DOI - PMC - PubMed
    1. Veronese N, Demurtas J, Soysal P, et al. ; Special Interest Groups in Systematic Reviews and Meta-analyses for healthy ageing Sarcopenia and Frailty and resilience in older persons of the European Geriatric Medicine Society (EuGMS). Sarcopenia and health-related outcomes: an umbrella review of observational studies. Eur Geriatr Med. 2019;10(6):853–862. 10.1007/s41999-019-00233-w - DOI - PubMed
    1. Kitamura A, Seino S, Abe T, et al. . Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults. J Cachexia Sarcopenia Muscle. 2021;12(1):30–38. 10.1002/jcsm.12651 - DOI - PMC - PubMed