. 2024 May;44(5):805-817.

doi: 10.1007/s00296-024-05542-3. Epub 2024 Mar 12.

Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study

Cristiana Sieiro Santos¹, Jun-Peng Chen², Elena Nikiphorou^{3

4}, Chi-Wei Tseng⁵, Carlos Enrique Toro Gutiérrez⁶, Ai Lyn Tan^{7

8}, Arvind Nune⁹, Esha Kadam¹⁰, Masataka Kuwana¹¹, Jessica Day^{12

13

14}, Sreoshy Saha¹⁵, Tsvetelina Velikova¹⁶, James B Lilleker^{17

18}, Carlo V Caballero-Uribe¹⁹, Parikshit Sen²⁰, Hector Chinoy^{17

21

22}, Rohit Aggarwal²³, Vikas Agarwal^#²⁴, Latika Gupta^{17

25

26}, Yi-Ming Chen^#^{27

28

29

30

31

32}; COVAD study group

Collaborators, Affiliations

Collaborators

COVAD study group:
Mahnoor Javaid, Naitica Darooka, Samuel Katsuyuki Shinjo, Ioannis Parodis, Abraham Edgar Gracia-Ramos, Johannes Knitza, Aarat Patel, Chris Wincup, Bhupen Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio García-De La Torre, Iris J Colunga-Pedraza, Javier Merayo-Chalico, Okwara Celestine Chibuzo, Russka Shumnalieva, Leonardo Santos Hoff, Lina El Kibbi, Hussein Halabi, Binit Vaidya, ATMTanveer Hasan, Babur Salim, Tamer Gheita, Miguel A Saavedra, Sinan Kardes, Laura Andreoli, Daniele Lini, Karen Schreiber, Melinda Nagy Vince, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C Pandya, Rakesh Kumar Pilania, Aman Sharma, MManesh Manoj, Vikas Gupta, Chengappa G Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R Pande, Kunal Chandwar, Akanksha Ghodke, Hiya Boro, Zoha Zahid Fazal, Döndü Üsküdar Cansu, Reşit Yıldırım, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Silvia Grignaschi, Alessandro Giollo, Alessia Alluno, Florenzo Ioannone, Marco Fornaro, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Jesús Loarce-Martos, Sergio Prieto-González, Raquel Aranega Gonzalez, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Takahisa Gono, Stylianos Tomaras, Fabian Nikolai Proft, Marie-Therese Holzer, Margarita Aleksandrovna Gromova, Or Aharonov, Zoltán Griger, Ihsane Hmamouchi, Imane El Bouchti, Zineb Baba, Margherita Giannini, François Maurier, Julien Campagne, Alain Meyer, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Marie Hudson, Océane Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, Álvaro Arbeláez, Javier Cajas, José António Pereira Silva, João Eurico Fonseca, Olena Zimba, Uyi Ima-Edomwonyi, Ibukunoluwa Dedeke, Emorinken Airenakho, Nwankwo Henry Madu, Abubakar Yerima, Hakeem Olaosebikan, A Becky, Oruma Devi Koussougbo, Elisa Palalane, Ho So, Manuel Francisco Ugarte-Gil, Lyn Chinchay, José Proaño Bernaola, Victorio Pimentel, Hanan Mohammed Fathi, Reem Hamdy A Mohammed, Ghita Harifi, Yurilís Fuentes-Silva, Karoll Cabriza, Jonathan Losanto, Nelly Colaman, Antonio Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Lilith Stange Nunez, MCristian Vergara, Jossiell Then Báez, Hugo Alonzo, Carlos Benito Santiago Pastelin, Rodrigo García Salinas, Alejandro Quiñónez Obiols, Nilmo Chávez, Andrea Bran Ordóñez, Gil Alberto Reyes Llerena, Radames Sierra-Zorita, Dina Arrieta, Eduardo Romero Hidalgo, Ricardo Saenz, MIdania Escalante, Wendy Calapaqui, Ivonne Quezada, Gabriela Arredondo, Akira Yoshida, Keina Yomono, John D Pauling, Ashima Makol, Tulika Chatterjee, Wanruchada Katchamart, Phonpen Akarawatcharangura Goo, Dzifa Dey, Lorenzo Cavagna, Marcin Milchert, Nelly Ziade, Oliver Distler

Affiliations

¹ Rheumatologist at Complejo Asistencial Universitario de León, Castilla and Leon, Spain.
² Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan.
³ Centre for Rheumatic Diseases, King's College London, London, UK.
⁴ Rheumatology Department, King's College Hospital, London, UK.
⁵ Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.
⁶ Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Cali, Colombia.
⁷ NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
⁸ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
⁹ Southport and Ormskirk Hospital NHS Trust, Southport, PR8 6PN, UK.
¹⁰ Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India.
¹¹ Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
¹² Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.
¹³ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
¹⁴ Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
¹⁵ Mymensingh Medical College, Mymensingh, Bangladesh.
¹⁶ Medical Faculty, Sofia University St. Kliment Ohridski, 1 Kozyak Str., 1407, Sofia, Bulgaria.
¹⁷ Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK.
¹⁸ Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK.
¹⁹ Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia.
²⁰ Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, Delhi, 110002, India.
²¹ National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.
²² Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.
²³ Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
²⁴ Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
²⁵ Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
²⁶ Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
²⁷ Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
²⁸ Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
²⁹ Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
³⁰ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
³¹ Precision Medicine Research Center, College of Medicine, National Chung Hsing University, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
³² School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. ymchen1@vghtc.gov.tw.

^# Contributed equally.

PMID: 38470502
DOI: 10.1007/s00296-024-05542-3

Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study

Cristiana Sieiro Santos et al. Rheumatol Int. 2024 May.

. 2024 May;44(5):805-817.

doi: 10.1007/s00296-024-05542-3. Epub 2024 Mar 12.

Authors

Collaborators

COVAD study group:
Mahnoor Javaid, Naitica Darooka, Samuel Katsuyuki Shinjo, Ioannis Parodis, Abraham Edgar Gracia-Ramos, Johannes Knitza, Aarat Patel, Chris Wincup, Bhupen Barman, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio García-De La Torre, Iris J Colunga-Pedraza, Javier Merayo-Chalico, Okwara Celestine Chibuzo, Russka Shumnalieva, Leonardo Santos Hoff, Lina El Kibbi, Hussein Halabi, Binit Vaidya, ATMTanveer Hasan, Babur Salim, Tamer Gheita, Miguel A Saavedra, Sinan Kardes, Laura Andreoli, Daniele Lini, Karen Schreiber, Melinda Nagy Vince, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C Pandya, Rakesh Kumar Pilania, Aman Sharma, MManesh Manoj, Vikas Gupta, Chengappa G Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R Pande, Kunal Chandwar, Akanksha Ghodke, Hiya Boro, Zoha Zahid Fazal, Döndü Üsküdar Cansu, Reşit Yıldırım, Armen Yuri Gasparyan, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Silvia Grignaschi, Alessandro Giollo, Alessia Alluno, Florenzo Ioannone, Marco Fornaro, Lisa S Traboco, Suryo Anggoro Kusumo Wibowo, Jesús Loarce-Martos, Sergio Prieto-González, Raquel Aranega Gonzalez, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Takahisa Gono, Stylianos Tomaras, Fabian Nikolai Proft, Marie-Therese Holzer, Margarita Aleksandrovna Gromova, Or Aharonov, Zoltán Griger, Ihsane Hmamouchi, Imane El Bouchti, Zineb Baba, Margherita Giannini, François Maurier, Julien Campagne, Alain Meyer, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Marie Hudson, Océane Landon-Cardinal, Wilmer Gerardo Rojas Zuleta, Álvaro Arbeláez, Javier Cajas, José António Pereira Silva, João Eurico Fonseca, Olena Zimba, Uyi Ima-Edomwonyi, Ibukunoluwa Dedeke, Emorinken Airenakho, Nwankwo Henry Madu, Abubakar Yerima, Hakeem Olaosebikan, A Becky, Oruma Devi Koussougbo, Elisa Palalane, Ho So, Manuel Francisco Ugarte-Gil, Lyn Chinchay, José Proaño Bernaola, Victorio Pimentel, Hanan Mohammed Fathi, Reem Hamdy A Mohammed, Ghita Harifi, Yurilís Fuentes-Silva, Karoll Cabriza, Jonathan Losanto, Nelly Colaman, Antonio Cachafeiro-Vilar, Generoso Guerra Bautista, Enrique Julio Giraldo Ho, Lilith Stange Nunez, MCristian Vergara, Jossiell Then Báez, Hugo Alonzo, Carlos Benito Santiago Pastelin, Rodrigo García Salinas, Alejandro Quiñónez Obiols, Nilmo Chávez, Andrea Bran Ordóñez, Gil Alberto Reyes Llerena, Radames Sierra-Zorita, Dina Arrieta, Eduardo Romero Hidalgo, Ricardo Saenz, MIdania Escalante, Wendy Calapaqui, Ivonne Quezada, Gabriela Arredondo, Akira Yoshida, Keina Yomono, John D Pauling, Ashima Makol, Tulika Chatterjee, Wanruchada Katchamart, Phonpen Akarawatcharangura Goo, Dzifa Dey, Lorenzo Cavagna, Marcin Milchert, Nelly Ziade, Oliver Distler

Affiliations

¹ Rheumatologist at Complejo Asistencial Universitario de León, Castilla and Leon, Spain.
² Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan.
³ Centre for Rheumatic Diseases, King's College London, London, UK.
⁴ Rheumatology Department, King's College Hospital, London, UK.
⁵ Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.
⁶ Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Cali, Colombia.
⁷ NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
⁸ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
⁹ Southport and Ormskirk Hospital NHS Trust, Southport, PR8 6PN, UK.
¹⁰ Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India.
¹¹ Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
¹² Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.
¹³ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
¹⁴ Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.
¹⁵ Mymensingh Medical College, Mymensingh, Bangladesh.
¹⁶ Medical Faculty, Sofia University St. Kliment Ohridski, 1 Kozyak Str., 1407, Sofia, Bulgaria.
¹⁷ Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK.
¹⁸ Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK.
¹⁹ Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia.
²⁰ Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, Delhi, 110002, India.
²¹ National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.
²² Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK.
²³ Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
²⁴ Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
²⁵ Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
²⁶ Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
²⁷ Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
²⁸ Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
²⁹ Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
³⁰ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
³¹ Precision Medicine Research Center, College of Medicine, National Chung Hsing University, Taichung City, Taiwan. ymchen1@vghtc.gov.tw.
³² School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan. ymchen1@vghtc.gov.tw.

^# Contributed equally.

PMID: 38470502
DOI: 10.1007/s00296-024-05542-3

Abstract

COVID-19 has been suggested as a possible trigger of disease flares in patients with rheumatoid arthritis (RA). However, factors associated with disease flares remain unknown. This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database. Factors associated with disease flare-ups were determined by multivariate logistic regression analysis. The analysis comprised 1928 patients with RA who participated in the COVAD study. Younger age, Caucasian ethnicity, comorbidities with obstructive chronic pulmonary disease and asthma were associated with COVID-19 breakthrough infection. Moreover, younger age (odds ratio (OR): 0.98, 95% CI 0.96-0.99, p < 0.001), ethnicity other than Asian, past history of tuberculosis (OR: 3.80, 95% CI 1.12-12.94, p = 0.033), treatment with methotrexate (OR: 2.55, 95% CI: 1.56-4.17, p < 0.001), poor global physical health (OR: 1.07, 95% CI 1.00-1.15, p = 0.044) and mental health (OR: 0.91, 95% CI 0.87-0.95, p < 0.001) were independent factors associated disease flares in patients with RA. Our study highlights the impact of socio-demographic factors, clinical characteristics and mental health on disease flares in patients with RA. These insights may help determine relevant strategies to proactively manage RA patients at risk of flares.

Keywords: Breakthrough infection; COVID-19; Disease flares; Rheumatoid arthritis.

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References

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Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study

Collaborators

Affiliations

Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study

Authors

Collaborators

Affiliations

Abstract

References

MeSH terms

Substances

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous