. 2024 Oct 1;63(10):2660-2669.

doi: 10.1093/rheumatology/keae162.

Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study

Tiffany Dal Santo^{1

2}, Danielle B Rice^{3

4}, Marie-Eve Carrier¹, Gabrielle Virgili-Gervais¹, Brooke Levis¹, Linda Kwakkenbos^{5

6

7}, Meira Golberg¹, Susan J Bartlett^{8

9}, Amy Gietzen¹⁰, Karen Gottesman¹¹, Geneviève Guillot¹², Marie Hudson^{1

8}, Laura K Hummers¹³, Vanessa L Malcarne^{14

15}, Maureen D Mayes¹⁶, Luc Mouthon^{17

18}, Michelle Richard^{19

20}, Maureen Sauvé^{19

21}, Robyn K Wojeck²², Marie-Claude Geoffroy^{2

23}, Andrea Benedetti^{8

9

24

25}, Brett D Thombs^{1

2

8

25

26

27}; SPIN Investigators

Collaborators, Affiliations

Collaborators

SPIN Investigators:
Catherine Fortuné, Claire E Adams, Ghassan El-Baalbaki, Kim Fligelstone, Tracy Frech, Daphna Harel, Richard S Henry, Monique Hinchcliff, Sindhu R Johnson, Maggie Larche, Catarina Leite, Christelle Nguyen, Karen Nielsen, Janet Pope, François Rannou, Tatiana Sofia Rodriguez-Reyna, Anne A Schouffoer, Maria E Suarez-Almazor, Christian Agard, Laurent Alric, Marc André, Floryan Beaslay, Elana J Bernstein, Sabine Berthier, Lyne Bissonnette, Sophie Blaise, Eva Bories, Alessandra Bruns, Carlotta Cacciatore, Patricia Carreira, Marion Casadevall, Benjamin Chaigne, Lorinda Chung, Benjamin Crichi, Thylbert Deltombe, Christopher Denton, Tannvir Desroche, Robyn Domsic, James V Dunne, Bertrand Dunogue, Regina Fare, Dominique Farge-Bancel, Paul R Fortin, Loraine Gauzère, Anne Gerber, Jessica Gordon, Brigitte Granel-Rey, Aurélien Guffroy, Geneviève Gyger, Eric Hachulla, Sabrina Hoa, Michael Hughes, Alena Ikic, Niall Jones, Suzanne Kafaja, Nader Khalidi, Kimberly Lakin, Marc Lambert, David Launay, Yvonne C Lee, Paul Legendre, Hélène Maillard, Nancy Maltez, Joanne Manning, Isabelle Marie, Maria Martin Lopez, Thierry Martin, Ariel Masetto, François Maurier, Arsène Mekinian, Sheila Melchor Díaz, Morgane Mourguet, Mandana Nikpour, Louis Olagne, Vincent Poindron, Susanna Proudman, Grégory Pugnet, Loïc Raffray, Alexis Régent, Frederic Renou, Sébastien Rivière, David Robinson, Esther Rodríguez Almazar, Sophie Roux, Perrine Smets, Vincent Sobanski, Robert Spiera, Virginia Steen, Evelyn Sutton, Carter Thorne, Damien Vagner, John Varga, Pearce Wilcox, Mara Cañedo Ayala, Vanessa Cook, Sophie Hu, Elsa-Lynn Nassar, Marieke Alexandra Neyer, Sabrina Provencher

Affiliations

¹ Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
² Department of Psychiatry, McGill University, Montreal, QC, Canada.
³ Department of Psychology, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
⁴ Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
⁵ Department of Clinical Psychology, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
⁶ Department of IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.
⁷ Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
⁸ Department of Medicine, McGill University, Montreal, QC, Canada.
⁹ Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
¹⁰ National Scleroderma Foundation, Tri-State Chapter, Buffalo, NY, USA.
¹¹ National Scleroderma Foundation, Los Angeles, CA, USA.
¹² Sclérodermie Québec, Longueuil, QC, Canada.
¹³ Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, Baltimore, MD, USA.
¹⁴ Department of Psychology, San Diego State University, San Diego, CA, USA.
¹⁵ San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA.
¹⁶ Department of Internal Medicine, Division of Rheumatology, University of Texas McGovern School of Medicine, Houston, TX, USA.
¹⁷ Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin, Paris, France.
¹⁸ Assistance Publique Hôpitaux de Paris-Centre, Hôpital Cochin, Université Paris Cité, Paris, France.
¹⁹ Scleroderma Canada, Hamilton, ON, Canada.
²⁰ Scleroderma Atlantic, Halifax, NS, Canada.
²¹ Scleroderma Society of Ontario, Hamilton, ON, Canada.
²² College of Nursing, University of Rhode Island, Kingston, RI, USA.
²³ Douglas Research Centre, McGill Group for Suicide Studies, Montreal, QC, Canada.
²⁴ Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, QC, Canada.
²⁵ Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
²⁶ Biomedical Ethics Unit, McGill University, Montreal, QC, Canada.
²⁷ Department of Psychology, McGill University, Montreal, QC, Canada.

PMID: 38471107
PMCID: PMC11443018
DOI: 10.1093/rheumatology/keae162

Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study

Tiffany Dal Santo et al. Rheumatology (Oxford). 2024.

. 2024 Oct 1;63(10):2660-2669.

doi: 10.1093/rheumatology/keae162.

Authors

Collaborators

SPIN Investigators:
Catherine Fortuné, Claire E Adams, Ghassan El-Baalbaki, Kim Fligelstone, Tracy Frech, Daphna Harel, Richard S Henry, Monique Hinchcliff, Sindhu R Johnson, Maggie Larche, Catarina Leite, Christelle Nguyen, Karen Nielsen, Janet Pope, François Rannou, Tatiana Sofia Rodriguez-Reyna, Anne A Schouffoer, Maria E Suarez-Almazor, Christian Agard, Laurent Alric, Marc André, Floryan Beaslay, Elana J Bernstein, Sabine Berthier, Lyne Bissonnette, Sophie Blaise, Eva Bories, Alessandra Bruns, Carlotta Cacciatore, Patricia Carreira, Marion Casadevall, Benjamin Chaigne, Lorinda Chung, Benjamin Crichi, Thylbert Deltombe, Christopher Denton, Tannvir Desroche, Robyn Domsic, James V Dunne, Bertrand Dunogue, Regina Fare, Dominique Farge-Bancel, Paul R Fortin, Loraine Gauzère, Anne Gerber, Jessica Gordon, Brigitte Granel-Rey, Aurélien Guffroy, Geneviève Gyger, Eric Hachulla, Sabrina Hoa, Michael Hughes, Alena Ikic, Niall Jones, Suzanne Kafaja, Nader Khalidi, Kimberly Lakin, Marc Lambert, David Launay, Yvonne C Lee, Paul Legendre, Hélène Maillard, Nancy Maltez, Joanne Manning, Isabelle Marie, Maria Martin Lopez, Thierry Martin, Ariel Masetto, François Maurier, Arsène Mekinian, Sheila Melchor Díaz, Morgane Mourguet, Mandana Nikpour, Louis Olagne, Vincent Poindron, Susanna Proudman, Grégory Pugnet, Loïc Raffray, Alexis Régent, Frederic Renou, Sébastien Rivière, David Robinson, Esther Rodríguez Almazar, Sophie Roux, Perrine Smets, Vincent Sobanski, Robert Spiera, Virginia Steen, Evelyn Sutton, Carter Thorne, Damien Vagner, John Varga, Pearce Wilcox, Mara Cañedo Ayala, Vanessa Cook, Sophie Hu, Elsa-Lynn Nassar, Marieke Alexandra Neyer, Sabrina Provencher

Affiliations

¹ Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
² Department of Psychiatry, McGill University, Montreal, QC, Canada.
³ Department of Psychology, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
⁴ Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
⁵ Department of Clinical Psychology, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
⁶ Department of IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.
⁷ Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
⁸ Department of Medicine, McGill University, Montreal, QC, Canada.
⁹ Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
¹⁰ National Scleroderma Foundation, Tri-State Chapter, Buffalo, NY, USA.
¹¹ National Scleroderma Foundation, Los Angeles, CA, USA.
¹² Sclérodermie Québec, Longueuil, QC, Canada.
¹³ Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, Baltimore, MD, USA.
¹⁴ Department of Psychology, San Diego State University, San Diego, CA, USA.
¹⁵ San Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA, USA.
¹⁶ Department of Internal Medicine, Division of Rheumatology, University of Texas McGovern School of Medicine, Houston, TX, USA.
¹⁷ Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin, Paris, France.
¹⁸ Assistance Publique Hôpitaux de Paris-Centre, Hôpital Cochin, Université Paris Cité, Paris, France.
¹⁹ Scleroderma Canada, Hamilton, ON, Canada.
²⁰ Scleroderma Atlantic, Halifax, NS, Canada.
²¹ Scleroderma Society of Ontario, Hamilton, ON, Canada.
²² College of Nursing, University of Rhode Island, Kingston, RI, USA.
²³ Douglas Research Centre, McGill Group for Suicide Studies, Montreal, QC, Canada.
²⁴ Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montreal, QC, Canada.
²⁵ Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
²⁶ Biomedical Ethics Unit, McGill University, Montreal, QC, Canada.
²⁷ Department of Psychology, McGill University, Montreal, QC, Canada.

PMID: 38471107
PMCID: PMC11443018
DOI: 10.1093/rheumatology/keae162

Abstract

Objectives: To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors.

Methods: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.

Results: Among 2385 participants, the mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in the multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56).

Conclusion: Physical function is impaired for many individuals with SSc and is associated with multiple disease factors.

Keywords: PROMIS-29; physical function; scleroderma; systemic sclerosis.

PubMed Disclaimer

Figures

**Figure 1.**
Forest plot including mean physical function scores in months since enrolment in the SPIN Cohort. The U.S. general population mean is represented by the dotted line. Means, standard deviations, and number of participants at each assessment are shown in Supplementary Table S3, available at *Rheumatology* online

**Figure 2.**
Forest plot including mean physical function scores (95% CIs) by country, disease subtype, and sex. The U.S. general population mean is represented by the dotted line

**Figure 3.**
Bar chart including the proportion of participants with physical function scores by classification by country, disease subtype, and sex

See this image and copyright information in PMC

References

1. Denton CP, Khanna D. Systemic sclerosis. Lancet 2017;390:1685–99. - PubMed
1. Painter P, Stewart AL, Carey S. Physical functioning: definitions, measurement, and expectations. Adv Ren Replace Ther 1999;6:110–23. - PubMed
1. Garber CE, Greaney ML, Riebe D et al. Physical and mental health-related correlates of physical function in community dwelling older adults: a cross sectional study. BMC Geriatr 2010;10:6. - PMC - PubMed
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Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study

Collaborators

Affiliations

Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study

Authors

Collaborators

Affiliations

Abstract

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical