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. 2024;80(3):143-152.
doi: 10.1159/000538232. Epub 2024 Mar 12.

The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data

Kateřina Koudelková  1 , Petr Waldauf  2 , Petr Wohl  3 , Michal Šenkyřík  4 , Petr Beneš  5 , Pavel Kohout  6 , Jiří Vejmelka  6 , Jan Maňák  7 , Pavel Těšínský  1 , František Novák  8 , Eva Meisnerová  8 , Filip Fencl  9 , Jan Gojda  1
Affiliations

The Czech Home Parenteral Nutrition Registry REDNUP: Comprehensive Analysis of Adult Patients' Data

Kateřina Koudelková et al. Ann Nutr Metab. 2024.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Ann Nutr Metab. 2024;80(6):354. doi: 10.1159/000542030. Epub 2024 Oct 18. Ann Nutr Metab. 2024. PMID: 39427646 Free PMC article. No abstract available.

Abstract

Introduction: Home parenteral nutrition (HPN) is the primary treatment modality for patients with chronic intestinal failure, one of the least common organ failures. This article provides a retrospective analysis of the data collected on HPN patients in the Czech Republic over the past 30 years.

Methods: National registry data were collected using a standardised online form based on the OASIS registry (Oley - A.S.P.E.N. Information System) across all centres providing HPN in the Czech Republic. Data collected prospectively from adult patients in the HPN program were analysed in the following categories: epidemiology, demographics, underlying syndrome, diagnosis, complications, and teduglutide therapy prevalence.

Results: The registry identified a total of 1,838 adult patient records, reflecting almost 1.5 million individual catheter days. The prevalence of HPN has risen considerably over the last few decades, currently reaching 5.5 per 100,000 population. The majority of patients have short bowel syndrome and GI obstruction, with cancer being the most prevalent underlying disease. Catheter-related bloodstream infections have been the most prevalent acute complication. However, the incidence in 2022 was only 0.15 per 1,000 catheter days. The study also observed an increase in the prevalence of patients on palliative HPN over the last decade.

Conclusion: This study presents a thorough analysis of data from the Czech REgistr Domaci NUtricni Podpory (REDNUP) registry. It shows an increasing prevalence of HPN, namely, in the palliative patient group. The sharing of national data can improve understanding of this rare condition and facilitate the development of international guidelines.

Keywords: Chronic intestinal failure; Epidemiology; Home parenteral nutrition; National registry.

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Conflict of interest statement

K.K., J.M., and P.W2.: Takeda (honoraria); M.Š.: Takeda, USA, BBraun, Germany, Fresenius-Kabi, Nestlé, France, and Danone, Switzerland (honoraria); P.B.: Takeda (honoraria and consulting fees); P.K.: Takeda, USA (honoraria), Nestlé, France (honoraria), and Danone, Switzerland (honoraria); J.V.: Takeda, USA (honoraria); J.M.: VectivBio, Switzerland (study contract); P.T. and J.G.: Takeda, USA (honoraria), and VectivBio, Switzerland (study contract); F.N., P.W1., E.M., and F.F.: none.

Figures

Fig. 1.
Fig. 1.
Per-year prevalence of HPN patients and the average number of catheter days per patient during the years 2007–2022.
Fig. 2.
Fig. 2.
Annual incidence of patients, i.e., new patients per year, according to the prognostic classification at the HPN initiation. Patients are expected to be lifetime-dependent, to be weaned off HPN and palliative HPN. Note: The category was newly introduced to the registry in 2017, and the preceding years were collected retrospectively.
Fig. 3.
Fig. 3.
Prevalence of syndromes over diagnosis across all patients in the REDNUP (n = 1,838).
Fig. 4.
Fig. 4.
Catheter-related bloodstream infection incidence in years, in events per 1,000 catheter days.
Fig. 5.
Fig. 5.
Duration of HPN administration (n = 1,826).
Fig. 6.
Fig. 6.
Survival of patients on HPN. Kaplan-Meier analysis (n = 1,838).
See this image and copyright information in PMC

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References

    1. Pironi L, Boeykens K, Bozzetti F, Joly F, Klek S, Lal S, et al. . ESPEN guideline on home parenteral nutrition. Clin Nutr. 2020;39(6):1645–66. - PubMed
    1. Baxter JP, Fayers PM, Bozzetti F, Kelly D, Joly F, Wanten G, et al. . An international study of the quality of life of adult patients treated with home parenteral nutrition. Clin Nutr. 2019;38(4):1788–96. - PubMed
    1. Anděl M, Filip K, Brůček P. Long-term home parenteral nutrition using a totally implanted cannulation system. Cas Lek Cesk. 1992;131(13):395–8. - PubMed
    1. Wanden-Berghe C, Virgili Casas N, Cuerda Compés C, Ramos Boluda E, Pereira Cunill JL, Maíz Jiménez MI, et al. . [Home and ambulatory artificial nutrition (NADYA) group report: home parenteral nutrition in Spain, 2019]. Nutr Hosp. 2021;38(6):1304–9. - PubMed
    1. Neelis EG, Roskott AM, Dijkstra G, Wanten GJ, Serlie MJ, Tabbers MM, et al. . Presentation of a nationwide multicenter registry of intestinal failure and intestinal transplantation. Clin Nutr. 2016;35(1):225–9. - PubMed