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. 2024 Mar 1;14(5):525.
doi: 10.3390/diagnostics14050525.

A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies

Edoardo Beatrici  1   2 , Nicola Frego  1   2 , Giuseppe Chiarelli  1   2 , Federica Sordelli  1   2 , Stefano Mancon  1   2 , Cesare Saitta  1   2 , Fabio De Carne  1   2 , Giuseppe Garofano  1   2 , Paola Arena  1   2 , Pier Paolo Avolio  1   2 , Andrea Gobbo  1   2 , Alessandro Uleri  1   2 , Roberto Contieri  1   2 , Marco Paciotti  2 , Massimo Lazzeri  2 , Rodolfo Hurle  2 , Paolo Casale  2 , Nicolò Maria Buffi  1   2 , Giovanni Lughezzani  1   2
Affiliations

A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies

Edoardo Beatrici et al. Diagnostics (Basel). .

Abstract

Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases.

Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa).

Results: In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15-37.8; p = 0.035).

Conclusions: mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted.

Keywords: diagnosis; imaging; micro-ultrasound; multiparametric MRI; prostate biopsy; prostate cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Micro-ultrasound image displaying a typical benign pattern with no lesions indicative of prostate cancer. The observed pattern is characterized by hyper-echogenic regions with ductal patches, categorized as PRI-MUS I, alongside small, orderly ductal structures, known as the ‘Swiss Cheese’ pattern, designated as PRI-MUS II.
Figure 2
Figure 2
Micro-ultrasound image showing a smudgy (PRI-MUS IV) lesion in the peripheral zone of the prostate with an associated capsular bulging but no visible capsular breach.
See this image and copyright information in PMC

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