Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

doi:10.3390/cancers16051045

Review

. 2024 Mar 4;16(5):1045.

doi: 10.3390/cancers16051045.

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

Affiliations

¹ Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London W1W 7TY, UK.
² Cancer Section, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
³ Department of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK.
⁴ Department of Biomedical and Clinical Science, University of Milano, 20157 Milan, Italy.
⁵ National Institute for Health Research Bristol Biomedical Research Centre, Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK.
⁶ Department of Gastrointestinal Surgery, North Bristol NHS Trust, Bristol BS10 5NB, UK.
⁷ The Sarcoma, Melanoma and Rare Tumours Unit, The Royal Marsden Hospital, Institute Cancer of Research, London SW3 6JJ, UK.
⁸ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
⁹ North of England Bone and Soft Tissue Tumour Service, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
¹⁰ Hamlyn Centre for Robotic Surgery, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.
¹¹ Head and Neck Unit, The Royal Marsden Hospitals, London SW3 6JJ, UK.
¹² Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.
¹³ Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

PMID: 38473402
PMCID: PMC10931077
DOI: 10.3390/cancers16051045

Review

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

Stefano Giuliani et al. Cancers (Basel). 2024.

. 2024 Mar 4;16(5):1045.

doi: 10.3390/cancers16051045.

Authors

Affiliations

¹ Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London W1W 7TY, UK.
² Cancer Section, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
³ Department of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK.
⁴ Department of Biomedical and Clinical Science, University of Milano, 20157 Milan, Italy.
⁵ National Institute for Health Research Bristol Biomedical Research Centre, Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK.
⁶ Department of Gastrointestinal Surgery, North Bristol NHS Trust, Bristol BS10 5NB, UK.
⁷ The Sarcoma, Melanoma and Rare Tumours Unit, The Royal Marsden Hospital, Institute Cancer of Research, London SW3 6JJ, UK.
⁸ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
⁹ North of England Bone and Soft Tissue Tumour Service, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
¹⁰ Hamlyn Centre for Robotic Surgery, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.
¹¹ Head and Neck Unit, The Royal Marsden Hospitals, London SW3 6JJ, UK.
¹² Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.
¹³ Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

PMID: 38473402
PMCID: PMC10931077
DOI: 10.3390/cancers16051045

Abstract

This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available "off-the-shelf" injectable fluorescent probes for safer and more effective solid tumor resection.

Keywords: fluorophores; monoclonal antibodies; solid malignancies; surgical oncology; targeted fluorescence-guided surgery.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Conjugation of anti-GD2 monoclonal antibodies (mAbs) with IRDye800CW and in vitro and in vivo binding experiments on neuroblastoma cells expressing the GD2 antigen.

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References

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[1] Zahavi D., Weiner L. Monoclonal Antibodies in Cancer Therapy. Antibodies. 2020;9:34. doi: 10.3390/antib9030034. - DOI - PMC - PubMed

[2] Zahavi D., Weiner L. Monoclonal Antibodies in Cancer Therapy. Antibodies. 2020;9:34. doi: 10.3390/antib9030034. - DOI - PMC - PubMed

[3] Larson S.M., Carrasquillo J.A., Cheung N.-K.V., Press O.W. Radioimmunotherapy of human tumours. Nat. Rev. Cancer. 2015;15:347–360. doi: 10.1038/nrc3925. - DOI - PMC - PubMed

[4] Larson S.M., Carrasquillo J.A., Cheung N.-K.V., Press O.W. Radioimmunotherapy of human tumours. Nat. Rev. Cancer. 2015;15:347–360. doi: 10.1038/nrc3925. - DOI - PMC - PubMed

[5] Nagaya T., Nakamura Y.A., Choyke P.L., Kobayashi H. Fluorescence-Guided Surgery. Front. Oncol. 2017;7:314. doi: 10.3389/fonc.2017.00314. - DOI - PMC - PubMed

[6] Nagaya T., Nakamura Y.A., Choyke P.L., Kobayashi H. Fluorescence-Guided Surgery. Front. Oncol. 2017;7:314. doi: 10.3389/fonc.2017.00314. - DOI - PMC - PubMed

[7] Nguyen Q.T., Tsien R.Y. Fluorescence-guided surgery with live molecular navigation—A new cutting edge. Nat. Rev. Cancer. 2013;13:653–662. doi: 10.1038/nrc3566. - DOI - PMC - PubMed

[8] Nguyen Q.T., Tsien R.Y. Fluorescence-guided surgery with live molecular navigation—A new cutting edge. Nat. Rev. Cancer. 2013;13:653–662. doi: 10.1038/nrc3566. - DOI - PMC - PubMed

[9] Paraboschi I., De Coppi P., Stoyanov D., Anderson J., Giuliani S. Fluorescence imaging in pediatric surgery: State-of-the-art and future perspectives. J. Pediatr. Surg. 2021;56:655–662. doi: 10.1016/j.jpedsurg.2020.08.004. - DOI - PubMed

[10] Paraboschi I., De Coppi P., Stoyanov D., Anderson J., Giuliani S. Fluorescence imaging in pediatric surgery: State-of-the-art and future perspectives. J. Pediatr. Surg. 2021;56:655–662. doi: 10.1016/j.jpedsurg.2020.08.004. - DOI - PubMed

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Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

Affiliations

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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Abstract

Conflict of interest statement

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