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. 2024 Mar 6;16(5):1077.
doi: 10.3390/cancers16051077.

The Combined Use of Inflammation Markers, Modified Glasgow Prognostic Score, and Sarculator Nomogram in Extremity Soft Tissue Sarcoma: A Multicenter Observational Study

Tomoki Nakamura  1 , Satoshi Takenaka  2 , Hidetatsu Outani  3 , Tomohito Hagi  1 , Hironari Tamiya  2 , Yoshinori Imura  3 , Kunihiro Asanuma  1 , Akihiro Sudo  1
Affiliations

The Combined Use of Inflammation Markers, Modified Glasgow Prognostic Score, and Sarculator Nomogram in Extremity Soft Tissue Sarcoma: A Multicenter Observational Study

Tomoki Nakamura et al. Cancers (Basel). .

Abstract

Background: Sarculator is a validated nomogram designed to predict overall survival (OS) in extremity soft tissue sarcoma (STS). Inflammation plays a critical role in cancer development and progression. There were no reports which investigated the relationship between Sarculator and inflammation.

Methods: A total of 217 patients with extremity STS were included. The Sarculator-predicted 10-year probability of OS (pr-OS) was stratified into two subgroups: lower risk (10-year pr-OS ≥ 60%) and higher risk (10-year pr-OS < 60%). The modified Glasgow prognostic score (mGPS) varied from 0 to 2.

Results: Out of the 217 patients, 67 were classified as higher risk, while 150 were lower risk. A total of 181 patients had an mGPS of 0, and 36 had a score of 1 or 2. The 5-year OS was 83.3%. When patients were divided into two groups according to the 10-year pr-OS, those with a higher risk had poorer OS than those with a lower risk. Among the patients with a higher risk, those with an mGPS of 1 or 2 had poorer OS compared to those with a score of 0.

Conclusions: The mGPS could potentially play an important role in identifying patients who are at high risk of death and metastasis in the higher-risk group on the Sarculator.

Keywords: Sarculator; modified Glasgow prognostic score; soft tissue sarcoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Kaplan–Meier curve showing the overall survival based on their 10-year predicted probability of overall survival (a: lower-risk group; b: higher-risk group).
Figure 2
Figure 2
Kaplan–Meier curve showing the overall survival in patients with higher risk based on their 10-year predicted probability of overall survival (a: mGPS of 0; b: mGPS of 1 or 2).
Figure 3
Figure 3
Kaplan–Meier curve showing the overall survival in patients with lower risk based on their 10-year predicted probability of overall survival (a: mGPS score of 0; b: HS-mGPS score of 1 or 2).
Figure 4
Figure 4
Kaplan–Meier curve showing the metastasis-free survival based on their 10-year predicted probability of overall survival (a: lower-risk group; b: higher-risk group).
See this image and copyright information in PMC

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