mTOR Signaling: Recent Progress

doi:10.3390/ijms25052587

Editorial

. 2024 Feb 23;25(5):2587.

doi: 10.3390/ijms25052587.

mTOR Signaling: Recent Progress

Antonios N Gargalionis¹, Kostas A Papavassiliou², Athanasios G Papavassiliou³

Affiliations

¹ Department of Biopathology, 'Eginition' Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
² 'Sotiria' Hospital, Medical School, First University Department of Respiratory Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
³ Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 38473834
PMCID: PMC10931642
DOI: 10.3390/ijms25052587

Editorial

mTOR Signaling: Recent Progress

Antonios N Gargalionis et al. Int J Mol Sci. 2024.

. 2024 Feb 23;25(5):2587.

doi: 10.3390/ijms25052587.

Authors

Antonios N Gargalionis¹, Kostas A Papavassiliou², Athanasios G Papavassiliou³

Affiliations

¹ Department of Biopathology, 'Eginition' Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
² 'Sotiria' Hospital, Medical School, First University Department of Respiratory Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
³ Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

PMID: 38473834
PMCID: PMC10931642
DOI: 10.3390/ijms25052587

Abstract

In the intricate landscape of human biology, the mechanistic target of rapamycin (mTOR) emerges as a key regulator, orchestrating a vast array of processes in health and disease [...].

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

1. Panwar V., Singh A., Bhatt M., Tonk R.K., Azizov S., Raza A.S., Sengupta S., Kumar D., Garg M. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct. Target. Ther. 2023;8:375. doi: 10.1038/s41392-023-01608-z. - DOI - PMC - PubMed
1. Gargalionis A.N., Papavassiliou K.A., Basdra E.K., Papavassiliou A.G. mTOR Signaling Components in Tumor Mechanobiology. Int. J. Mol. Sci. 2022;23:1825. doi: 10.3390/ijms23031825. - DOI - PMC - PubMed
1. Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177–189. doi: 10.1016/S0092-8674(02)00833-4. - DOI - PubMed
1. Dai X., Jiang C., Jiang Q., Fang L., Yu H., Guo J., Yan P., Chi F., Zhang T., Inuzuka H., et al. AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. Nat. Metab. 2023;5:265–276. doi: 10.1038/s42255-022-00732-4. - DOI - PMC - PubMed
1. Menon S., Dibble C.C., Talbott G., Hoxhaj G., Valvezan A.J., Takahashi H., Cantley L.C., Manning B.D. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014;156:771–785. doi: 10.1016/j.cell.2013.11.049. - DOI - PMC - PubMed

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[1] Panwar V., Singh A., Bhatt M., Tonk R.K., Azizov S., Raza A.S., Sengupta S., Kumar D., Garg M. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct. Target. Ther. 2023;8:375. doi: 10.1038/s41392-023-01608-z. - DOI - PMC - PubMed

[2] Panwar V., Singh A., Bhatt M., Tonk R.K., Azizov S., Raza A.S., Sengupta S., Kumar D., Garg M. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct. Target. Ther. 2023;8:375. doi: 10.1038/s41392-023-01608-z. - DOI - PMC - PubMed

[3] Gargalionis A.N., Papavassiliou K.A., Basdra E.K., Papavassiliou A.G. mTOR Signaling Components in Tumor Mechanobiology. Int. J. Mol. Sci. 2022;23:1825. doi: 10.3390/ijms23031825. - DOI - PMC - PubMed

[4] Gargalionis A.N., Papavassiliou K.A., Basdra E.K., Papavassiliou A.G. mTOR Signaling Components in Tumor Mechanobiology. Int. J. Mol. Sci. 2022;23:1825. doi: 10.3390/ijms23031825. - DOI - PMC - PubMed

[5] Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177–189. doi: 10.1016/S0092-8674(02)00833-4. - DOI - PubMed

[6] Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002;110:177–189. doi: 10.1016/S0092-8674(02)00833-4. - DOI - PubMed

[7] Dai X., Jiang C., Jiang Q., Fang L., Yu H., Guo J., Yan P., Chi F., Zhang T., Inuzuka H., et al. AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. Nat. Metab. 2023;5:265–276. doi: 10.1038/s42255-022-00732-4. - DOI - PMC - PubMed

[8] Dai X., Jiang C., Jiang Q., Fang L., Yu H., Guo J., Yan P., Chi F., Zhang T., Inuzuka H., et al. AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. Nat. Metab. 2023;5:265–276. doi: 10.1038/s42255-022-00732-4. - DOI - PMC - PubMed

[9] Menon S., Dibble C.C., Talbott G., Hoxhaj G., Valvezan A.J., Takahashi H., Cantley L.C., Manning B.D. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014;156:771–785. doi: 10.1016/j.cell.2013.11.049. - DOI - PMC - PubMed

[10] Menon S., Dibble C.C., Talbott G., Hoxhaj G., Valvezan A.J., Takahashi H., Cantley L.C., Manning B.D. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014;156:771–785. doi: 10.1016/j.cell.2013.11.049. - DOI - PMC - PubMed

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mTOR Signaling: Recent Progress

Affiliations

mTOR Signaling: Recent Progress

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