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. 2024 Mar 6;25(5):3067.
doi: 10.3390/ijms25053067.

OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder

Agnieszka Boroń  1 , Aleksandra Suchanecka  2 , Krzysztof Chmielowiec  3 , Małgorzata Śmiarowska  4 , Jolanta Chmielowiec  3 , Aleksandra Strońska-Pluta  2 , Remigiusz Recław  5 , Anna Grzywacz  2
Affiliations

OPRM1 Gene Polymorphism in Women with Alcohol Use Disorder

Agnieszka Boroń et al. Int J Mol Sci. .

Abstract

The main aims of the present study were to explore the relationship of the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and to try to find out whether any specific features may influence alcohol cravings and be a prognostic for alcohol dependency and treatment in AUD women. Our study found a notable correlation between openness and the interaction of the ORIM1 gene and AUD. The alcohol use disorder subjects with genotype AG showed a higher level of openness compared to the control group with genotypes AG (p = 0.0001) and AA (p = 0.0125). The alcohol use disorder subjects with the AA genotype displayed higher levels of openness than the control group with genotype AG (p = 0.0271). However, the alcohol use disorder subjects with the AA genotype displayed lower levels of openness than the control group with genotype GG (p = 0.0212). Our study indicates that openness as a personality trait is correlated with the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women. These are the first data and results exploring such a relationship between opioid and alcohol pathways and the mental construction of AUD women. Personality traits such as openness to experience and neuroticism might play major roles in the addiction mechanism, especially in genetically predisposed females, independent of the reward system involved in the emotional disturbances that coexist with anxiety and depression.

Keywords: AUD; OPRM1; alcohol; gene; polymorphism; women.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Interaction between the alcohol use disorder (AUD) subjects/control (C) and OPRIM rs1074287 and Openness scale. Means and standard errors are presented.
See this image and copyright information in PMC

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