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Meta-Analysis
. 2024 Feb 26;16(5):656.
doi: 10.3390/nu16050656.

Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review

Marta Stelmach-Mardas  1 , Wojciech Warchoł  2 , Aleksandra Garczyk  1 , Emilia Warchoł  1 , Jolanta Korczak  3 , Maria Litwiniuk  4 , Beata Brajer-Luftmann  5 , Marcin Mardas  6
Affiliations
Meta-Analysis

Influence of Androgen Deprivation Therapy on the Development of Sarcopenia in Patients with Prostate Cancer: A Systematic Review

Marta Stelmach-Mardas et al. Nutrients. .

Abstract

The changes in body composition during androgen deprivation therapy (ADT) in patients suffering from prostate cancer (PCa) are recognized by professionals more often as biomarker for effective treatment. The aim of this study was to investigate the impact of ADT on the sarcopenia development in PCa. The following databases were used: PubMed, Embase, Web of Science and Scopus databases. Out of 2183 studies, 7 were included in this review. The fixed-effect model was used in the meta-analysis. A significant increase in SATI (Subcutaneous Adipose Tissue Index) of 0.32 (95% CI: 0.13-0.51) p = 0.001, decrease in SMI (Skeletal Muscle Index) of -0.38 (95% CI: -0.57 to -0.19) p < 0.0001, and SMD (Skeletal Muscle Density) of -0.46 (95% CI: -0.69 to -0.24) p < 0.0001 were observed. No statistical association was visible between ADT and changes in BMI (Body Mass Index), 0.05 (95% CI: -0.18-0.28), p = 0.686, and VATI (Visceral Adipose Tissue Index): 0.17 (95% CI: -0.02 to 0.37), p = 0.074. In conclusion, the ADT significantly contributes to the body composition changes and sarcopenia development.

Keywords: ADT; androgen deprivation therapy; prostate cancer; prostatic neoplasm; sarcopenia; systematic review.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Scheme 1
Scheme 1
Flow diagram describing study selection.
Figure 1
Figure 1
Forest plot (left) and funnel plot (right) meta-analyses of BMI.
Figure 2
Figure 2
Forest plot (left) and funnel plot (right) meta-analyses of SATI.
Figure 3
Figure 3
Forest plot (left) funnel plot (right) meta-analyses of SMD.
Figure 4
Figure 4
Forest plot (left) funnel plot (right) meta-analyses of SMI.
Figure 5
Figure 5
Forest plot (left) funnel plot (right) meta-analyses of VATI.
See this image and copyright information in PMC

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