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Review
. 2024 Feb 28;16(5):681.
doi: 10.3390/nu16050681.

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Ewa Baranowska-Wójcik  1 , Anna Winiarska-Mieczan  2 , Piotr Olcha  3 , Małgorzata Kwiecień  2 , Karolina Jachimowicz-Rogowska  2 , Łukasz Nowakowski  4 , Andrzej Miturski  4 , Krzysztof Gałczyński  5
Affiliations
Review

Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Ewa Baranowska-Wójcik et al. Nutrients. .

Abstract

Dysbiosis of the microbiota in the gastrointestinal tract can induce the development of gynaecological tumours, particularly in postmenopausal women, by causing DNA damage and alterations in metabolite metabolism. Dysbiosis also complicates cancer treatment by influencing the body's immune response and disrupting the sensitivity to chemotherapy drugs. Therefore, it is crucial to maintain homeostasis in the gut microbiota through the effective use of food components that affect its structure. Recent studies have shown that polyphenols, which are likely to be the most important secondary metabolites produced by plants, exhibit prebiotic properties. They affect the structure of the gut microbiota and the synthesis of metabolites. In this review, we summarise the current state of knowledge, focusing on the impact of polyphenols on the development of gynaecological tumours, particularly endometrial cancer, and emphasising that polyphenol consumption leads to beneficial modifications in the structure of the gut microbiota.

Keywords: endometrial cancer; gut microbiota; gynaecological tumours; polyphenols; prebiotics.

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Conflict of interest statement

No potential conflicts of interest were reported by the authors.

Figures

Figure 1
Figure 1
Research strategy employed in the review of available literature.
Figure 2
Figure 2
Food products with recognized health-promoting effects containing polyphenols.
Figure 3
Figure 3
Metabolism of polyphenols.
See this image and copyright information in PMC

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