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Randomized Controlled Trial
. 2024 Mar 5;16(5):739.
doi: 10.3390/nu16050739.

Combined Effect of Early Nutrition Therapy and Rehabilitation for Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Prospective Randomized Controlled Trial

Yohei Oyama  1   2 , Hiroomi Tatsumi  1 , Hiroko Takikawa  3 , Natsuko Taniguchi  4 , Yoshiki Masuda  1
Affiliations
Randomized Controlled Trial

Combined Effect of Early Nutrition Therapy and Rehabilitation for Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Prospective Randomized Controlled Trial

Yohei Oyama et al. Nutrients. .

Abstract

The effectiveness of rehabilitation programs (RP) for chronic obstructive pulmonary disease (COPD) exacerbation remains controversial. However, few studies have investigated the combined effects of exercise and nutritional therapy. This study aimed to determine the effects of combined nutritional therapy on the physical function and nutritional status of patients with COPD exacerbation who underwent early RP. A randomized controlled trial was conducted in patients hospitalized for COPD exacerbations. Patients were assigned to receive a regular diet in addition to RP (control group) or RP and nutrition therapy (intervention group). Physical function, including quadricep strength and body composition, was assessed. The intervention group was administered protein-rich oral nutritional supplements. A total of 38 patients with negligible baseline differences were included in the analysis. The intervention group showed a notably greater change in quadriceps strength. Lean body mass and skeletal muscle indices markedly decreased in the control group but were maintained in the intervention group. Logistic regression analysis identified nutritional therapy as a significant factor associated with increased muscle strength. No serious adverse events were observed in either group. Therefore, nutritional therapy combined with RP is safe and effective for improving exercise function while maintaining body composition in patients with COPD exacerbation.

Keywords: chronic obstructive pulmonary disease; exacerbation; nutrition therapy; rehabilitation program.

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Conflict of interest statement

H.T. received lecture fees from Tsumura & Co. and an industry–academia collaborative research grant from Otsuka Pharmaceutical Factory, Inc. Y.M. received lecture fees from MSD K.K., Asahi Kasei Pharma Corp., Japan Blood Product, and an industry–academia collaborative research grant from Jimro Co., Ltd. The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of this study. IP; interstitial pneumonia, RP; rehabilitation program.
See this image and copyright information in PMC

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