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Review
. 2024 Mar 11:18:11782234241236358.
doi: 10.1177/11782234241236358. eCollection 2024.

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Reyhaneh Azhari Rad  1 , Yasaman Naghdi  1 , Mobina Majidi Jamalabadi  2 , Sima Masoumi  3 , Leila Rezakhani  4   5 , Morteza Alizadeh  6
Affiliations
Review

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Reyhaneh Azhari Rad et al. Breast Cancer (Auckl). .

Abstract

Despite recent improvements in detecting and managing breast cancer (BC), it continues to be a major worldwide health concern that annually affects millions of people. Exploring the anti-BC potentials of natural compounds has received a lot of scientific attention due to their multi-target mode of action and good safety profiles because of these unmet needs. Drugs made from herbs are secure and have a lot fewer negative effects than those made from synthetic materials. Early stage patients benefit from breast-conserving surgery, but the risk of local recurrence remains, necessitating implanted scaffolds. These scaffolds provide residual cancer cell killing and tailored drug delivery. This review looks at plant extract-infused tissue engineering scaffolds, which provide a novel approach to treating BC. By offering patient individualized, safer treatments, these scaffolds could completely change how BC is treated.

Keywords: Tissue engineering; breast cancer; plant extracts; scaffolds; treatment.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Treatment of BC with plant extract–loaded scaffold.
Figure 2.
Figure 2.
Distribution of cancer types and BC: (A) Distribution of cancer incidence and mortality among different types of cancer in 185 countries, BC is the important most commonly identified cancer with a total of 2.3 million new cases (11.7%), (B) distribution of BC cases and deaths by world area (2020), and (C) estimated number of BC cases and mortality from 2020 to 2040, by the level of Human Development Index (HDI).
Figure 3.
Figure 3.
Different methods of fabrication scaffolds for BC studies.
See this image and copyright information in PMC

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