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Review
. 2024 Feb 27:12:1336717.
doi: 10.3389/fchem.2024.1336717. eCollection 2024.

Commercial hydrogel product for drug delivery based on route of administration

Amin Raeisi  1   2 , Fatemeh Farjadian  1
Affiliations
Review

Commercial hydrogel product for drug delivery based on route of administration

Amin Raeisi et al. Front Chem. .

Abstract

Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant amounts of biological fluids or water. Hydrogels possess several favorable properties, including flexibility, stimulus-responsiveness, versatility, and structural composition. They can be categorized according to their sources, synthesis route, response to stimulus, and application. Controlling the cross-link density matrix and the hydrogels' attraction to water while they're swelling makes it easy to change their porous structure, which makes them ideal for drug delivery. Hydrogel in drug delivery can be achieved by various routes involving injectable, oral, buccal, vaginal, ocular, and transdermal administration routes. The hydrogel market is expected to grow from its 2019 valuation of USD 22.1 billion to USD 31.4 billion by 2027. Commercial hydrogels are helpful for various drug delivery applications, such as transdermal patches with controlled release characteristics, stimuli-responsive hydrogels for oral administration, and localized delivery via parenteral means. Here, we are mainly focused on the commercial hydrogel products used for drug delivery based on the described route of administration.

Keywords: buccal; commercial products; drug delivery; hydrogel; oral; routes of administration; transdermal; vaginal.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Application of hydrogel for drug delivery based on route of administration.
FIGURE 2
FIGURE 2
Classification of hydrogel products based on different parameters.
FIGURE 3
FIGURE 3
(A) Dual cross-linking hydrogel. (B) Nanocomposite hydrogel. (C) Slide-ring hydrogel.
FIGURE 4
FIGURE 4
(1) preserving the drug in a low-pH environment. (2) Hydrogen bonds between polymer chains cause the carrier to become complex.
FIGURE 5
FIGURE 5
The synthesis and biomedical application of PVA-DOPA@NPs-Dex mucoadhesive film enhances mucoadhesion for buccal drug delivery. PVA: poly (vinyl alcohol), DOPA: 3,4-dihydroxy-D-phenylalanine, NPs: nanoparticles, Dex: dexamethasone. Adopted from (Hu et al., 2021).
FIGURE 6
FIGURE 6
The application of hydrogels in various ocular regions.
See this image and copyright information in PMC

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