Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

doi:10.2147/JPR.S445171

Review

. 2024 Mar 8:17:953-963.

doi: 10.2147/JPR.S445171. eCollection 2024.

Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

Ke Ma^#¹, Zhixiang Cheng^#², Hao Jiang^#³, Zhangya Lin^#⁴, Chuansheng Liu^#⁵, Xianguo Liu^#⁶, Lijuan Lu^#⁷, Yan Lu^#⁸, Wei Tao^#⁹, Suoliang Wang^#¹⁰, Xiaoqiu Yang^#¹¹, Qishan Yi^#¹², Xiaomei Zhang^#¹³, Ying Zhang^#¹⁴, Yanqing Liu^#¹⁵

Affiliations

¹ Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
² Department of Algology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
³ Department of Algology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
⁴ Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
⁵ Department of Algology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
⁶ Pain Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's Republic of China.
⁷ Department of Pain Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.
⁸ Department of Algology, Xijing Hospital, The Fourth Military Medical University, Xian, People's Republic of China.
⁹ Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen, People's Republic of China.
¹⁰ Department of Algology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China.
¹¹ Department of Algology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
¹² Department of Algology, The Yibin First People's Hospital Affiliated Chongqing Medical University, Yibin, People's Republic of China.
¹³ Department of Algology, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
¹⁴ Department of Algology. Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, People's Republic of China.
¹⁵ Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

^# Contributed equally.

PMID: 38476873
PMCID: PMC10929561
DOI: 10.2147/JPR.S445171

Review

Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

Ke Ma et al. J Pain Res. 2024.

. 2024 Mar 8:17:953-963.

doi: 10.2147/JPR.S445171. eCollection 2024.

Authors

Affiliations

¹ Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
² Department of Algology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
³ Department of Algology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
⁴ Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
⁵ Department of Algology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
⁶ Pain Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's Republic of China.
⁷ Department of Pain Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.
⁸ Department of Algology, Xijing Hospital, The Fourth Military Medical University, Xian, People's Republic of China.
⁹ Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen, People's Republic of China.
¹⁰ Department of Algology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China.
¹¹ Department of Algology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
¹² Department of Algology, The Yibin First People's Hospital Affiliated Chongqing Medical University, Yibin, People's Republic of China.
¹³ Department of Algology, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
¹⁴ Department of Algology. Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, People's Republic of China.
¹⁵ Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

^# Contributed equally.

PMID: 38476873
PMCID: PMC10929561
DOI: 10.2147/JPR.S445171

Abstract

Ion channel drugs have been increasing used for chronic pain management with progress in the development of selective calcium channel modulators. Although ion channel drugs have been proven safe and effective in clinical practice, uncertainty remains regarding its use to treat chronic pain. To standardize the clinical practice of ion channel drug for the treatment of chronic pain, the National Health Commission Capacity Building and Continuing Education Center for Pain Diagnosis and Treatment Special Ability Training Project established an expert group to form an expert consensus on the use of ion channel drugs for the treatment of chronic pain after repeated discussions on existing medical evidence combined with the well clinical experience of experts. The consensus provided information on the mechanism of action of ion channel drugs and their recommendations, caution use, contraindications, and precautions for their use in special populations to support doctors in their clinical decision-making.

Keywords: chronic pain; ion channel drugs; voltage-gated calcium channels; voltage-gated sodium channel.

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Conflict of interest statement

The authors declare that they have no competing interests in this work.

References

1. Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International Classification of Diseases (ICD-11). Pain. 2019;160(1):19–27. doi:10.1097/j.pain.0000000000001384 - DOI - PubMed
1. Wang JL, Zhang WJ, Luo WJ, et al. Investigation on the status quo of patients in pain department in some areas based on ICD-11 chronic pain classification. Chin J Pain Med. 2019;25(4):267–275.
1. Yamamoto PA, Conchon Costa AC, Lauretti GR, et al. Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice. Pharmacogenomics. 2019;20(13):971–982. doi:10.2217/pgs-2019-0066 - DOI - PubMed
1. Rogers M, Tang L, Madge DJ, et al. The role of sodium channels in neuropathic pain. Semin Cell Dev Biol. 2006;17(5):571–581. doi:10.1016/j.semcdb.2006.10.009 - DOI - PubMed
1. Markman JD, Dworkin RH. Ion channel targets and treatment efficacy in neuropathic pain. J Pain. 2006;7(Suppl 1):S38–47. doi:10.1016/j.jpain.2005.09.008 - DOI - PubMed

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[1] Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International Classification of Diseases (ICD-11). Pain. 2019;160(1):19–27. doi:10.1097/j.pain.0000000000001384 - DOI - PubMed

[2] Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International Classification of Diseases (ICD-11). Pain. 2019;160(1):19–27. doi:10.1097/j.pain.0000000000001384 - DOI - PubMed

[3] Wang JL, Zhang WJ, Luo WJ, et al. Investigation on the status quo of patients in pain department in some areas based on ICD-11 chronic pain classification. Chin J Pain Med. 2019;25(4):267–275.

[4] Wang JL, Zhang WJ, Luo WJ, et al. Investigation on the status quo of patients in pain department in some areas based on ICD-11 chronic pain classification. Chin J Pain Med. 2019;25(4):267–275.

[5] Yamamoto PA, Conchon Costa AC, Lauretti GR, et al. Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice. Pharmacogenomics. 2019;20(13):971–982. doi:10.2217/pgs-2019-0066 - DOI - PubMed

[6] Yamamoto PA, Conchon Costa AC, Lauretti GR, et al. Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice. Pharmacogenomics. 2019;20(13):971–982. doi:10.2217/pgs-2019-0066 - DOI - PubMed

[7] Rogers M, Tang L, Madge DJ, et al. The role of sodium channels in neuropathic pain. Semin Cell Dev Biol. 2006;17(5):571–581. doi:10.1016/j.semcdb.2006.10.009 - DOI - PubMed

[8] Rogers M, Tang L, Madge DJ, et al. The role of sodium channels in neuropathic pain. Semin Cell Dev Biol. 2006;17(5):571–581. doi:10.1016/j.semcdb.2006.10.009 - DOI - PubMed

[9] Markman JD, Dworkin RH. Ion channel targets and treatment efficacy in neuropathic pain. J Pain. 2006;7(Suppl 1):S38–47. doi:10.1016/j.jpain.2005.09.008 - DOI - PubMed

[10] Markman JD, Dworkin RH. Ion channel targets and treatment efficacy in neuropathic pain. J Pain. 2006;7(Suppl 1):S38–47. doi:10.1016/j.jpain.2005.09.008 - DOI - PubMed

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Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

Affiliations

Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China

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Abstract

Conflict of interest statement

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Abstract

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