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. 2024 Mar;28(3):265-272.
doi: 10.5005/jp-journals-10071-24656.

Retrospective Analysis of Clinical Characteristics and Outcomes of Pregnant Women with SARS-CoV-2 Infections Admitted to Intensive Care Units in India (Preg-CoV): A Multicenter Study

Sharmili Sinha  1 , Gunchan Paul  2 , Bhagyesh A Shah  3 , Tejas Karmata  4 , Naveen Paliwal  5 , Jayesh Dobariya  6 , Behera Srikant  7 , Aarti Mona  2 , Vipul P Thakkar  3 , Gunadhar Padhi  8 , Pooja Bihani  5 , Saurabh Karmakar  9 , Jay Prakash  10 , Mayurdhwaja Rath  1 , Anand Mishra  11 , Vinay Singhal  12 , Alpesh Ruparelia  6 , Alisha Chaudhury  13 , Alaukik Goyal  8
Affiliations

Retrospective Analysis of Clinical Characteristics and Outcomes of Pregnant Women with SARS-CoV-2 Infections Admitted to Intensive Care Units in India (Preg-CoV): A Multicenter Study

Sharmili Sinha et al. Indian J Crit Care Med. 2024 Mar.

Abstract

Aim: The aim was to examine the outcomes of pregnant women admitted to intensive care unit with coronavirus disease-2019 (COVID-19) infection during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in India. The primary outcome of the study was maternal mortality at day 30. The secondary outcomes were the intensive care unit (ICU) and hospital length of stay, fetal mortality and preterm delivery.

Materials and methods: This was a retrospective multicentric cohort study. Ethical clearance was obtained. All pregnant women of the 15-45-year age admitted to ICUs with SARS-CoV-2 infection during 1st March 2020 to 31st October, 2021 were included.

Results: Data were collected from nine centers and for 211 obstetric patients admitted to the ICU with a confirmed diagnosis of COVID-19. They were divided in to two groups as per their SpO2 (saturation of peripheral oxygen) level at admission on room air, that is, normal SpO2 group (SpO2 > 90%) and low SpO2 group (SpO2 < 90%). The mean age was (30.06 ± 4.25) years and the gestational age was 36 ± 8 weeks. The maternal mortality rate was10.53%. The rate of fetal death and preterm delivery was 7.17 and 28.22%, respectively. The average ICU and hospital length of stay (LOS) were 6.35 ± 8.56 and 6.78 ± 6.04 days, respectively. The maternal mortality (6.21 vs 43.48%, p < 0.001), preterm delivery (26.55 vs 52.17%, p = 0.011) and fetal death (5.08 vs 26.09%, p = 0.003) were significantly higher in the low SpO2 group.

Conclusion: The overall maternal mortality among critically ill pregnant women affected with COVID-19 infection was 10.53%. The rate of preterm birth and fetal death were 28.22 and 7.17%, respectively. These adverse maternal and fetal outcomes were significantly higher in those admitted with low SpO2 (<90%) at admission compared with those with normal SpO2.

How to cite this article: Sinha S, Paul G, Shah BA, Karmata T, Paliwal N, Dobariya J, et al. Retrospective Analysis of Clinical Characteristics and Outcomes of Pregnant Women with SARS-CoV-2 Infections Admitted to Intensive Care Units in India (Preg-CoV): A Multicenter Study. Indian J Crit Care Med 2024;28(3):265-272.

Keywords: Coronavirus disease-2019; Intensive care unit; Maternal mortality; Obstetric critical care; Pregnant women.

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Conflict of interest statement

Source of support: Funding and technological support was received from Indian Society of Critical Care Medicine (ISCCM). Conflict of interest: None

Figures

Fig. 1
Fig. 1
Overall distribution of patients
Figs 2A and B
Figs 2A and B
Maternal outcomes. (A) Shows the more maternal mortality rate in normal SpO2 group (6.21%) and hypoxic group (43.48%); (B) The ICU length of stay (LOS) and hospital LOS were comparable among both the groups (depicted in mean of days). *shows that differences were statistically significant (p < 0.001)
Fig. 3
Fig. 3
Fetal outcome parameters. Shows incidence of IUD and preterm in normal SpO2 group and hypoxic group and the differences among the groups were statistically significant (p = 0.003 and p = 0.011, respectively)
See this image and copyright information in PMC

References

    1. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 382:1708–1720. doi: 10.1056/NEJMoa2002032. - DOI - PMC - PubMed
    1. Villar J, Arif S, Gunier RB, Thiruvengadam R, Rauch S, Kholin A, et al. Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: The INTERCOVID multinational cohort study. JAMA Pediatr. 2021;175(8):817–826. doi: 10.1001/jamapediatrics.2021.1050. - DOI - PMC - PubMed
    1. DeBolt CA, Bianco A, Limaye MA, Silverstein J, Penfeld CA, Roman AS, et al. Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls. Am J Obstet Gynecol. 2021;224(5):510.e1–510.e12. doi: 10.1016/j.ajog.2020.11.022. - DOI - PMC - PubMed
    1. Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: Living systematic review and meta-analysis. BMJ. 2020;370:m3320. doi: 10.1136/bmj.m3320. - DOI - PMC - PubMed
    1. Crovetto F, Crispi F, Llurba E, Pascal R, Larroya M, Trilla C, et al. Impact of severe acute respiratory syndrome coronavirus 2 infection on pregnancy outcomes: A population-based study. Clin Infect Dis. 2021;73(10):1768–1775. doi: 10.1093/cid/ciab104. - DOI - PMC - PubMed

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