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. 2023 Dec 5;101(12):862-870.

Hyperimmunoglobulinemia E and hereditary immune deficiencies

[Article in French]
Ilham Fadil  1 , Fatima Ailal  1   2 , Vivien Beziat  3   4 , Jean Laurent Casanova  3   4 , Bertrand Boisson  3   4 , Ahmed Aziz Bousfiha  1   2
Affiliations

Hyperimmunoglobulinemia E and hereditary immune deficiencies

[Article in French]
Ilham Fadil et al. Tunis Med. .

Abstract
in English, French

The detection of a high serum immunoglobulin E (IgE) level is first suggestive of allergy, atopy or parasitosis. However, some very high values can be a sign of more severe diseases. We propose a diagnostic strategy based on clinical and biological data to identify the various hereditary immune diseases that also present with abnormally high serum IgE levels.

La détection d’un taux élevé des immunoglobulines E (IgE) sériques est d’abord évocatrice d’allergie, d’atopie ou de parasitose. Cependant, certaines valeurs très élevées peuvent être le signe de maladies plus sévères. Nous proposons une stratégie diagnostique basée sur des données cliniques et biologiques pour identifier les différentes maladies héréditaires de l’immunité qui présentent également des niveaux d’IgE sériques anormalement élevés.

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