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Review
. 2024;30(8):589-596.
doi: 10.2174/0113816128291248240131102709.

Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease

Zaobin Chen  1 , Yongda Lin  1 , Jiali Wang  1 , Kaijin Yao  1 , Yina Xie  1 , Xiutian Chen  1 , Tianbiao Zhou  1
Affiliations
Review

Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease

Zaobin Chen et al. Curr Pharm Des. 2024.

Abstract

Chronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal function, and plays a crucial role in the pathophysiology and progression of the disease. Simultaneously, compound α-Ketoacid can bind nitrogen-containing metabolites in the blood and accelerate their excretion from the body, thereby reducing the level of metabolic waste, alleviating gastrointestinal reactions in patients, and reducing the inflammatory response and oxidative stress state of the body. Compound α-Ketoacid contains amino acids required by CKD patients. In this review, we explore the relationship between compound α-Ketoacid and microinflammation in patients with CKD. The review indicated that compound α-Ketoacid can improve the microinflammatory state in CKD patients by improving the nutritional status of CKD patients, improving patient's acid-base balance disorder, regulating oxidative stress, improving gut microbiota, and regulating abnormal lipid metabolism.

Keywords: Compound α-Ketoacid; abnormal lipid metabolism.; chronic kidney disease; gut microbiota; micro inflammatory; nitrogen-containing metabolites; oxidative stress.

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