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Comment
. 2024 Mar 12;57(3):403-406.
doi: 10.1016/j.immuni.2024.02.013.

IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging

Conor M Finlay  1 , Judith E Allen  2
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IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging

Conor M Finlay et al. Immunity. .
Free article

Abstract

Macrophages activated via the IL-4 receptor possess non-immune functions that support tissue homeostasis, but their specific role in aging is unknown. In this issue of Immunity, Zhou et al. show that IL-4 extends lifespan by inducing DNA repair pathways that protect macrophages from cellular senescence.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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