Complement-ary protection for all ages
- PMID: 38479358
- DOI: 10.1016/j.immuni.2024.02.010
Complement-ary protection for all ages
Abstract
Complement proteins form a proteolytic cascade to clear invading microbes. In a recent issue of Cell, Wu et al. and Xu et al. demonstrate two distinct complement systems operating in the gut, independent of circulating complement, and protecting against intestinal pathogens.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Complement in breast milk modifies offspring gut microbiota to promote infant health.Cell. 2024 Feb 1;187(3):750-763.e20. doi: 10.1016/j.cell.2023.12.019. Epub 2024 Jan 18. Cell. 2024. PMID: 38242132 Free PMC article.
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Gut complement induced by the microbiota combats pathogens and spares commensals.Cell. 2024 Feb 15;187(4):897-913.e18. doi: 10.1016/j.cell.2023.12.036. Epub 2024 Jan 26. Cell. 2024. PMID: 38280374 Free PMC article.
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