Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Mar 13;16(1):39.
doi: 10.1186/s13073-024-01311-w.

The exceptions that prove the rule-a historical view of bedaquiline susceptibility

Paolo Miotto  1 , Daniela M Cirillo  1 , Thomas Schön  2   3   4 , Claudio U Köser  5
Affiliations
Comment

The exceptions that prove the rule-a historical view of bedaquiline susceptibility

Paolo Miotto et al. Genome Med. .

Abstract

In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results.

Keywords: Mycobacterium tuberculosis; Bedaquiline susceptibility; Clinical trials; Resistance mutations.

PubMed Disclaimer

Conflict of interest statement

D.M.C. is the co-chair of the Working Group of the Stop TB Partnership New Diagnostics and is an unpaid member of the EUCAST subcommittee for antimicrobial susceptibility testing of mycobacteria, the CLSI mycobacterial committee, and the WHO Strategic and Technical Advisory Group for diagnostics. C.U.K. is a consultant for Becton Dickinson, the Foundation for Innovative New Diagnostics, the TB Alliance, and the WHO Regional Office for Europe. C.U.K.’s consulting for Becton Dickinson involves a collaboration with Janssen and Thermo Fisher Scientific. C.U.K. is an unpaid advisor to Cepheid and GenoScreen (GenoScreen covered related travel and accommodation expenses only). C.U.K. worked as a consultant for the Stop TB Partnership and the WHO Global TB Programme. C.U.K. gave a paid educational talk for Oxford Immunotec. C.U.K. collaborated with PZA Innovation and was an unpaid advisor to BioVersys.

Comment on

References

    1. Merker M, Kohl TA, Barilar I, Andres S, Fowler PW, Chryssanthou E, et al. Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex. Genome Med. 2020;12(1):27. doi: 10.1186/s13073-020-00726-5. - DOI - PMC - PubMed
    1. Majoor CJ, Magis-Escurra C, van Ingen J, Boeree MJ, van Soolingen D. Epidemiology of Mycobacterium bovis disease in humans, The Netherlands, 1993–2007. Emerg Infect Dis. 2011;17(3):457–463. doi: 10.3201/eid1703.101111. - DOI - PMC - PubMed
    1. Timm J, Bateson A, Solanki P, Paleckyte A, Witney AA, Rofael SAD, et al. Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanid. PLOS Glob Public Health. 2023;3(10):e0002283. doi: 10.1371/journal.pgph.0002283. - DOI - PMC - PubMed
    1. Beckert P, Sanchez-Padilla E, Merker M, Dreyer V, Kohl TA, Utpatel C, et al. MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era. Genome Med. 2020;12(1):104. doi: 10.1186/s13073-020-00793-8. - DOI - PMC - PubMed
    1. World Health Organization. Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance, 2nd ed. 2023. (https://iris.who.int/handle/10665/374061. Accessed 16 Jan 2024).

Publication types

MeSH terms