Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 17;22(15):2948-2952.
doi: 10.1039/d4ob00233d.

Vinylogous and stereoselective domino synthesis of pyrano[2,3- c]pyrroles from alkylidene meldrum's acids

Mariia Savchuk  1 , Giang Vo-Thanh  2 , Sylvain Oudeyer  1 , Hélène Beucher  1 , Jean-François Brière  1
Affiliations

Vinylogous and stereoselective domino synthesis of pyrano[2,3- c]pyrroles from alkylidene meldrum's acids

Mariia Savchuk et al. Org Biomol Chem. .

Abstract

A domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction was achieved with a series of alkylidene Meldrum's acid derivatives under simple operational conditions paving the way to novel pyrano[2,3-c]pyrroles in an excellent diasteroselectivity (>96 : 4), encompassing the relative control of three contiguous stereocenters.

PubMed Disclaimer

LinkOut - more resources