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. 1985 Jul;51(1):19-23.
doi: 10.1007/BF00320596.

Inhibition by pesticides of prostaglandin formation in blood platelets

H F Krug, J Berndt

Inhibition by pesticides of prostaglandin formation in blood platelets

H F Krug et al. Blut. 1985 Jul.

Abstract

Aggregation of human platelets was investigated after pre-incubation of platelet rich plasma with various pesticides of the carbamate type. Whereas N-methyl-carbamates (insecticides) inhibited the arachidonic acid induced aggregation, N-phenyl-carbamates (herbicides) had no effect. The influence of the different carbamates on aggregation coincided with their inhibition of thromboxane B2-formation. - DDE, a metabolite of the insecticide DDT, affected aggregation to a similar extent as N-methyl-carbamates. DDT, however, had no inhibitory activity.

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