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. 2024 Mar 14;24(1):807.
doi: 10.1186/s12889-024-18129-1.

Association of urinary chlorpyrifos, paraquat, and cyproconazole levels with the severity of fatty liver based on MRI

Peiqi Ma #  1 , Hongliang Gao #  2   3 , Ning Shen  4 , Lei Zhang  1 , Yang Zhang  1 , Kai Zheng  5 , Boqun Xu  6 , Jian Qin  7 , Jian He  8 , Tao Xu  2 , Yan Li  9 , Jing Wu  10 , Yushan Yuan  11 , Bin Xue  12   13
Affiliations

Association of urinary chlorpyrifos, paraquat, and cyproconazole levels with the severity of fatty liver based on MRI

Peiqi Ma et al. BMC Public Health. .

Erratum in

Abstract

Background: The objective of this study was to detect the urinary levels of chlorpyrifos, paraquat, and cyproconazole in residents living in Fuyang City and to analyze the correlation between these urinary pesticides levels and the severity of fatty liver disease (FLD).

Methods: All participants' fat fraction (FF) values were recorded by MRI (Magnetic resonance imaging). First-morning urine samples were collected from 53 participants from Fuyang Peoples'Hospital. The levels of three urinary pesticides were measured using β-glucuronidase hydrolysis followed by a. The results were analyzed by using Pearson correlation analysis and binary logistic regression analysis to reveal the correlation between three urinary pesticides and the severity of fatty liver.

Results: 53 individuals were divided into 3 groups based on the results from MRI, with 20 cases in the normal control group, 16 cases in the mild fatty liver group, and 17 cases in the moderate and severe fatty liver group. Urinary chlorpyrifos level was increased along with the increase of the severity of fatty liver. Urinary paraquat level was significantly higher both in the low-grade fatty liver group and moderate & serve grade fatty liver group compared with the control group. No significant differences in urinary cyproconazole levels were observed among the three groups. Furthermore, urinary chlorpyrifos and paraquat levels were positively correlated with FF value. And chlorpyrifos was the risk factor that may be involved in the development of FLD and Receiver Operating Characteristic curve (ROC curve) analysis showed that chlorpyrifos and paraquat may serve as potential predictors of FLD.

Conclusion: The present findings indicate urinary chlorpyrifos and paraquat were positively correlated with the severity of fatty liver. Moreover, urinary chlorpyrifos and paraquat have the potential to be considered as the predictors for development of FLD. Thus, this study may provide a new perspective from the environmental factors for the diagnosis, prevention, and treatment of FLD.

Keywords: Chlorpyrifos; Cyproconazole; Exposure; Fatty liver disease; Paraquat.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The schematic diagram of urinary pesticides detection and liver FF measurement
Fig. 2
Fig. 2
Urinary levels of chlorpyrifos, paraquat and cyproconazole. (A) Urinary concentration of chlorpyrifos; (B) Urinary concentration of paraquat; (C) Urinary concentration of cyproconazole
Fig. 3
Fig. 3
The association between three urinary pollutants levels and the severity of fatty liver. (A) The association between urinary chlorpyrifos level and FF%; (B) The association between urinary paraquat level and FF%; (C) The association between urinary cyproconazole level and FF%
Fig. 4
Fig. 4
Receiver operating characteristic curve analysis of the three Eds. (A) A ROC curve and AUC values showing the discriminating capacities of chlorpyrifos; (B) A ROC curve and AUC values showing the discriminating capacities of paraquat; (C) A ROC curve and AUC values showing the discriminating capacities of cyproconazole
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References

    1. Braun JM. Early-life exposure to EDCs: role in childhood obesity and neurodevelopment. Nat Rev Endocrinol. 2017;13(3):161–73. doi: 10.1038/nrendo.2016.186. - DOI - PMC - PubMed
    1. Balise VD, Cornelius-Green JN, Parmenter B, Baxter S, Kassotis CD, Rector RS, et al. Developmental exposure to a mixture of unconventional oil and gas chemicals increased risk-taking behavior, activity and energy expenditure in aged female mice after a metabolic challenge. Front Endocrinol (Lausanne) 2019;10:460. doi: 10.3389/fendo.2019.00460. - DOI - PMC - PubMed
    1. Yong CQY, Valiyaveettil S, Tang BL. Toxicity of Microplastics and nanoplastics in mammalian systems. Int J Environ Res Public Health. 2020;17(5). - PMC - PubMed
    1. Hadian Z, Samira S, Yazdanpanah H. Pesticide residues analysis in Iranian fruits and vegetables by Gas Chromatography-Mass Spectrometry. Iran J Pharm Res. 2019;18(1):275–85. - PMC - PubMed
    1. Ren Z, Jiang H. Risk cognition, agricultural cooperatives training, and farmers’ pesticide overuse: evidence from Shandong Province, China. Front Public Health. 2022;10:1032862. doi: 10.3389/fpubh.2022.1032862. - DOI - PMC - PubMed

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