Advances in Translational Nanotechnology: Challenges and Opportunities

Shyam S Mohapatra^{1

2

3}, Robert D Frisina⁴, Subhra Mohapatra^{2

3}, Kevin B Sneed¹, Eleni Markoutsa^{2

3}, Tao Wang^{2

3}, Rinku Dutta^{2

3}, Ratka Damnjanovic⁴, Manh-Huong Phan⁵, Daniel J Denmark¹, Manas R Biswal¹, Andrew R McGill^{2

3}, Ryan Green^{2

3}, Mark Howell^{2

3}, Payal Ghosh¹, Alejandro Gonzalez¹, Nadia Tasnim Ahmed¹, Brittney Borresen¹, Mitchell Farmer¹, Melissa Gaeta¹, Krishna Sharma¹, Christen Bouchard¹, Danielle Gamboni¹, Jamie Martin¹, Bianca Tolve¹, Mandip Singh⁶, Jack W Judy⁷, Chenzhong Li⁸, Swadeshmukul Santra⁹, Sylvia Daunert¹⁰, Elnaz Zeynaloo¹⁰, Ryan M Gelfand¹¹, Steven Lenhert¹², Eric S McLamore¹³, Dong Xiang¹³, Victoria Morgan¹³, Lisa E Friedersdorf¹⁴, Ratnesh Lal¹⁵, Thomas J Webster¹⁶, David P Hoogerheide¹⁷, Thanh Duc Nguyen¹⁸, Martin J D'Souza¹⁹, Mustafa Çulha²⁰, Pierre P D Kondiah²¹, Donald K Martin²²

Affiliations

¹ Taneja College of Pharmacy Graduate Programs, University of South Florida, Tampa, FL 33612, USA.
² Departments of Molecular Medicine and Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
³ James A. Haley Veterans Hospital, Tampa, FL 33612, USA.
⁴ Department of Chemical and Biomedical Engineering and Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33620, USA.
⁵ Department of Physics, University of South Florida, Tampa, FL 33620, USA.
⁶ College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
⁷ University of Florida Department of Electrical and Computer Engineering and Nanoscience Institute for Medical and Engineering Technology, Gainesville, FL 32611, USA.
⁸ Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.
⁹ NanoScience Technology Center, University of Central Florida, Burnett School of Biomedical Sciences, Department of Chemistry and Department of Materials Science and Engineering, Orlando, FL 32826, USA.
¹⁰ Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, and Department of Chemistry, Miami, FL 33124, USA.
¹¹ School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA.
¹² Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
¹³ Agricultural and Biological Engineering, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32603, USA.
¹⁴ National Nanotechnology Coordination Office, Alexandria, VA 22314, USA.
¹⁵ Center for Excellence in Nanomedicine and Engineering, University of California San Diego, IEM, La Jolla, CA 92093, USA.
¹⁶ Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
¹⁷ National Institute of Standards and Technology, Center for Neutron Research, Gaithersburg, MD 20899, USA.
¹⁸ Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
¹⁹ Department of Pharmaceutical Sciences, Nanotechnology Laboratory, Mercer University, Atlanta, GA 30341, USA.
²⁰ Knight Cancer Institute, Cancer Early Detection Advanced Research (CEDAR), Oregon Health and Science University, Portland, OR 97239, USA.
²¹ Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
²² Faculté de Pharmacie and TIMC-IMAG (UMR 5525), University Grenoble Alpes, SyNaBi, 38000 Grenoble, France.

PMID: 38486792
PMCID: PMC10938472
DOI: 10.3390/app10144881

Advances in Translational Nanotechnology: Challenges and Opportunities

Shyam S Mohapatra et al. Appl Sci (Basel). 2020.

. 2020;10(14):10.3390/app10144881.

doi: 10.3390/app10144881.

Authors

Affiliations

¹ Taneja College of Pharmacy Graduate Programs, University of South Florida, Tampa, FL 33612, USA.
² Departments of Molecular Medicine and Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
³ James A. Haley Veterans Hospital, Tampa, FL 33612, USA.
⁴ Department of Chemical and Biomedical Engineering and Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33620, USA.
⁵ Department of Physics, University of South Florida, Tampa, FL 33620, USA.
⁶ College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
⁷ University of Florida Department of Electrical and Computer Engineering and Nanoscience Institute for Medical and Engineering Technology, Gainesville, FL 32611, USA.
⁸ Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.
⁹ NanoScience Technology Center, University of Central Florida, Burnett School of Biomedical Sciences, Department of Chemistry and Department of Materials Science and Engineering, Orlando, FL 32826, USA.
¹⁰ Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, and Department of Chemistry, Miami, FL 33124, USA.
¹¹ School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA.
¹² Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
¹³ Agricultural and Biological Engineering, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL 32603, USA.
¹⁴ National Nanotechnology Coordination Office, Alexandria, VA 22314, USA.
¹⁵ Center for Excellence in Nanomedicine and Engineering, University of California San Diego, IEM, La Jolla, CA 92093, USA.
¹⁶ Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
¹⁷ National Institute of Standards and Technology, Center for Neutron Research, Gaithersburg, MD 20899, USA.
¹⁸ Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
¹⁹ Department of Pharmaceutical Sciences, Nanotechnology Laboratory, Mercer University, Atlanta, GA 30341, USA.
²⁰ Knight Cancer Institute, Cancer Early Detection Advanced Research (CEDAR), Oregon Health and Science University, Portland, OR 97239, USA.
²¹ Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa.
²² Faculté de Pharmacie and TIMC-IMAG (UMR 5525), University Grenoble Alpes, SyNaBi, 38000 Grenoble, France.

PMID: 38486792
PMCID: PMC10938472
DOI: 10.3390/app10144881

Abstract

The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research.

Keywords: NanoFlorida; biosensing; conference; microfluidics; nanomedicine; nanotechnology; nanotherapeutics; tissue engineering.

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Conflict of interest statement

Conflicts of Interest: The authors declare no conflict of interest.

Figures

**Figure 1.**
The SMARTHIP^™ can detect cell presence and function next to a hip implant in real time and possesses on-demand release of nanoparticles, antibiotics, anti-inflammatory agents, and more to ensure implant success. Further, all information can be sent to a hand-held device to provide personalized medicine.

**Figure 2.**
Examples of symbio-bots **(A-D**) that can be created in a bioinspired way (E). Each device is separated with a smart porous packaging that allows for duplex communication. Therapeutic cells (**A,B**) need a porous encapsulation that avoids an immune reaction and allows protection from both sides. They may be human cells, as MSC or specialized cells such as β-cell from Langherans islets (A), or other eukaryotic or prokaryotic cells (B). Panel (C) shows an IBFC linked to an electronic medical device. Panel (D) shows a generic device delivering a therapeutic molecule. Panel (E): Existing symbioses (i.e., microbiota or pregnancy) are a source of bio-inspiration to establish a duplex communication between the body and its implants. Regenerative medicine should embrace this concept of bioinspiration for better design and integration of implants, especially for future symbio-bots. (Reproduced with permission from [34].).

**Figure 3.**
Application space of scattering neutrons from biological materials. Applications at the intersections of basic science, materials research, and medicine are italicized.

See this image and copyright information in PMC

References

1. NNI Supplement to the President’s 2020 Budget. Available online: https://www.nano.gov/2020BudgetSupplement (accessed on 11 June 2020).
1. Alcaraz J-P; Menassol G; Penven G; Thélu J; El Ichi S; Zebda A; Cinquin P; Martin DK Challenges for the Implantation of Symbiotic Nanostructured Medical Devices. Appl. Sci 2020,10, 2923.
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Advances in Translational Nanotechnology: Challenges and Opportunities

Affiliations

Advances in Translational Nanotechnology: Challenges and Opportunities

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Grants and funding

LinkOut - more resources

Full Text Sources