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. 2024 Mar;14(3):1472-1476.
doi: 10.1016/j.apsb.2023.11.031. Epub 2023 Dec 4.

Commentary: Mammokine directs beige adipocytes to reserve energy for milk production in breast

Lina Tang  1 , Jianping Ye  1   2
Affiliations

Commentary: Mammokine directs beige adipocytes to reserve energy for milk production in breast

Lina Tang et al. Acta Pharm Sin B. 2024 Mar.
No abstract available

Keywords: Beige; Breast; Epitheliail cells; Thermogenesis; scRNA-seq.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cold-induced secretion of LCN2 from the luminal epithelial cells leads to beige cell whitening in the female breast. In the new study by Patel et al., the breast adipose tissues were collected from female mice treated with the room temperature (RT) or cold (4 °C) environment, respectively. The cell types and subsets of epithelial cells were investigated using single cell sequencing technology, which led to the finding that LCN2 expression was induced in the epithelial cells by the cold stimulation. The expression was restricted to the subset of luminal-alveolar (Lunimal-AV) of epithelial cells, but not the subset of luminal-hormone sensing (Luminal-HS) or luminal-hormone sensing alveolar (Luminal–HS–AV) epithelial cells. LCN2 was found to act on the beige adipocytes to reduce the thermogenesis activities leading to beige adipocyte whitening in the breast, which likely leads to reservation of energy for milk production in the breast.
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