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. 2024 Mar 15;134(6):e179942.
doi: 10.1172/JCI179942.

Bisphosphonates for osteoporosis: from bench to clinic

Teresita Bellido

Bisphosphonates for osteoporosis: from bench to clinic

Teresita Bellido. J Clin Invest. .
No abstract available

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Conflict of interest statement

Conflict of interest: The author has declared that no conflict of interest exists.

Figures

Figure 1
Figure 1. Distinct biological actions of bisphosphonates on bone cells explain the protective effects of the drugs on the skeleton.
Bisphosphonates inhibit the mevalonate pathway in osteoclasts, inducing their apoptosis, leading to inhibition of bone resorption. Additionally, the drugs open Cx43 hemichannels, promoting survival of osteocytes and osteoblasts, maintaining bone strength and bone formation.
See this image and copyright information in PMC

References

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