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. 2024 Jun;22(2):239-244.
doi: 10.1111/vco.12971. Epub 2024 Mar 15.

Sodium iodide symporter immunolabelling as a predictor of clinical iodide uptake in canine thyroid carcinoma: A preliminary study

Katelin V Dark  1 , Owen T Skinner  1 , Dae Young Kim  2 , James J Karnia  1 , Megan A Mickelson  1 , Charles A Maitz  1
Affiliations

Sodium iodide symporter immunolabelling as a predictor of clinical iodide uptake in canine thyroid carcinoma: A preliminary study

Katelin V Dark et al. Vet Comp Oncol. 2024 Jun.

Abstract

Thyroid follicular tumours may take up iodide via the sodium-iodide symporter. Knowledge of iodide uptake could then allow treatment with I-131 in dogs with high-risk tumours. The objective of this study was to determine the relationship between clinically detectable iodide uptake (as determined by scintigraphy and/or thyroxine concentrations) and sodium iodide symporter immunohistochemical labelling on histologically fixed thyroid tumours. Nineteen dogs were identified who were diagnosed with thyroid carcinoma and underwent surgery from November 2017 to July 2021. All had recorded thyroid hormone concentrations and were hyperthyroid and/or underwent preoperative nuclear imaging using planar scintigraphy (technetium-99m or I-123), or I-124 PET-CT. All dogs subsequently underwent surgery to remove the thyroid mass. Twenty-two tumours were submitted for histopathologic analysis immediately following surgery, which confirmed a diagnosis of thyroid carcinoma for each tumour. Images and/or thyroid hormone concentrations were reviewed for the included cases, and tumours were sorted into an avid/functional group (group 1) and a non-avid/functional group (group 2). The tumour tissues were re-examined histologically using sodium iodide symporter (NIS) immunohistochemistry (IHC). Group 1 contained 15 avid/functional tumours. Twelve of these tumours had membranous NIS IHC labelling. Group 2 contained 7 non-avid tumours. One of these tumours had membranous NIS IHC labelling. This resulted in an overall sensitivity and specificity for identification of avid/functional tumours with membranous NIS of 80.0% and 85.7%, respectively. NIS IHC may predict ion trapping in canine follicular thyroid tumours. Further studies using iodide-based imaging are warranted to better determine the clinical utility of this diagnostic modality.

Keywords: carcinoma; dog; immunohistochemistry; scintigraphy; symporter; thyroid gland.

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References

REFERENCES

    1. Liptak JM. Canine thyroid carcinoma. Clin Tech Small Anim Pract. 2007;22:75‐81.
    1. Wucherer KL, Wilke V. Thyroid cancer in dogs: an update based on 638 cases (1995–2005). J Am Anim Hosp Assoc. 2010;46:249‐254.
    1. Jankovic J, Dettwiler M, Fernandez MG, et al. Validation of immunohistochemistry for canine proteins involved in thyroid iodine uptake and their expression in canine follicular cell thyroid carcinomas (FTCs) and FTC‐derived organoids. Vet Pathol. 2021;58:1172‐1180.
    1. Latifi M, Skinner OT, Spoldi E, et al. Outcome and postoperative complications in 73 dogs with thyroid carcinoma with gross vascular invasion managed with thyroidectomy. Vet Comp Oncol. 2021;19:685‐696.
    1. Reagan JK, Selmic LE, Fallon C, et al. Complications and outcomes associated with unilateral thyroidectomy in dogs with naturally occurring thyroid tumors: 156 cases (2003–2015). J Am Vet Med Assoc. 2019;255:926‐932.

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