Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 15;44(1):137.
doi: 10.1007/s10792-024-03013-z.

Thickness of anterior sclera and corneal layers in systemic sclerosis

Emine Şeker Ün  1 , Gökhan Pekel  2 , Murat Tasci  3 , Alperen Bahar  4 , Evre Pekel  5 , Ebru Nevin Cetin  2 , Mustafa Subasi  6 , Veli Cobankara  7
Affiliations

Thickness of anterior sclera and corneal layers in systemic sclerosis

Emine Şeker Ün et al. Int Ophthalmol. .

Abstract

Purpose: To evaluate the thickness of anterior sclera and corneal layers in patients with systemic sclerosis.

Methods: The present cross-sectional study included 41 patients with systemic sclerosis and 41 age- and gender-matched healthy controls. The study and control groups were compared in terms of the thickness of anterior sclera, corneal epithelium, Bowman's layer, corneal stroma, and Descemet's membrane-endothelium complex. The thickness measurements were obtained using the anterior segment module of spectral-domain optical coherence tomography.

Results: The thickness of anterior sclera, corneal epithelium, Bowman's layer, and Descemet's membrane-endothelium complex were similar in the patients with systemic sclerosis and healthy controls (P > 0.05). Total corneal thickness at the apex was 511.1 ± 33.5 µm in the systemic sclerosis group and 528.4 ± 29.5 µm in the control group (P = 0.015). The corneal stroma was thinner in the systemic sclerosis patients compared to the healthy controls (P = 0.02).

Conclusions: The corneal stroma was thinner in the patients with systemic sclerosis compared to that of healthy controls, while the thickness of the anterior sclera was similar in both groups.

Keywords: Anterior sclera; Corneal layers; Scleroderma; Systemic sclerosis.

PubMed Disclaimer

References

    1. Fischer A, Zimovetz E, Ling C et al (2017) Humanistic and cost burden of systemic sclerosis: a review of the literature. Autoimmun Rev 16:1147–1154 - DOI - PubMed
    1. Kumanovics G, Pentek M, Bae S et al (2017) Assessment of skin involvement in systemic sclerosis. Rheumatology (Oxford) 56:v53–v66. https://doi.org/10.1093/rheumatology/kex202 - DOI - PubMed
    1. Romanowska-Próchnicka K, Walczyk M, Olesińska M (2016) Recognizing systemic sclerosis: comparative analysis of various sets of classification criteria. Reumatologia 54:296–305 - DOI - PubMed - PMC
    1. Postlethwaite AE, Harris LJ, Raza SH et al (2010) Pharmacotherapy of systemic sclerosis. Expert Opin Pharmacother 11:789–806 - DOI - PubMed - PMC
    1. de Gomes BAF, Santhiago MR, de Azevedo MN, Moraes HV Jr (2012) Evaluation of dry eye signs and symptoms in patients with systemic sclerosis. Graefes Arch Clin Exp Ophthalmol 250:1051–1056 - DOI

LinkOut - more resources