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. 2024 Jun:594:110051.
doi: 10.1016/j.virol.2024.110051. Epub 2024 Mar 8.

The investigation of the dynamics of changes in neutralizing antibody titers against type 5 adenovirus in the context of vaccination against a new coronavirus infection

I V Amosova  1 , T A Timoshicheva  2 , R A Kadyrova  1 , Y A Zabrodskaya  3 , V S Vakin  1 , M P Grudinin  1 , V V Dzytseva  4 , M S Khmelevsky  4 , D A Lioznov  5
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Free article

The investigation of the dynamics of changes in neutralizing antibody titers against type 5 adenovirus in the context of vaccination against a new coronavirus infection

I V Amosova et al. Virology. 2024 Jun.
Free article

Abstract

This research focuses on analyzing the dynamics of neutralizing antibody (nAbs) titers against type 5 adenovirus (Ad5) in the adult population of Russia following vaccination against the novel coronavirus infection with recombinant adenovirus type-5 COVID-19 vaccine (CanSino Biologics, China). The impact of the Ad5 vector on nAb titers was investigated using 302 blood serum samples from individuals who received a single dose of the Ad5-nCoV vector vaccine. The research revealed that 33.8% of adults in Russia had pre-existing anti-Ad5 nAbs before the pandemic. Notably, 40% of vaccinated individuals did not exhibit an increase in nAbs titers upon receiving the Ad5-based vaccine. However, in the group with no or low titers of anti-Ad5 nAbs (1:10-1:40), a significant 8-16-fold increase in nAb titers to Ad5 was observed.

Keywords: Adenovirus vector; COVID-19; Human adenovirus 5; Immunogenicity; Immunograph; Neutralizing antibodies; Vaccination.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lioznov D.A. reports financial support was provided by NPO Petrovax Pharm LLC, Russia. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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