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. 2024 Apr 15:389:578327.
doi: 10.1016/j.jneuroim.2024.578327. Epub 2024 Mar 5.

Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19

Nathália Gualberto Souza-Silva  1 , Daniela Valadão Rosa  1 , Jonas Jardim de Paula  2 , Roney Santos Coimbra  3 , Débora Marques Miranda  4 , Marco Aurélio Romano-Silva  5
Affiliations

Follow-up of cognitive impairment and inflammatory profile in individuals with mild COVID-19

Nathália Gualberto Souza-Silva et al. J Neuroimmunol. .

Abstract

Individuals who experience mild COVID-19 can suffer from long-lasting cognitive symptoms. Notably, 26% of these individuals experience difficulties with visuospatial abilities six months after infection. However, among those who initially exhibited visuoconstructive impairments, 66% showed improvement or complete reversal over time. Additionally, changes in cytokine levels, particularly CCL11, HGF, and CXCL10, were observed. These results suggest a potential link between ongoing cognitive issues and elevated levels of pro-inflammatory cytokines, which merits further investigation.

Keywords: Post-acute COVID-19 syndrome. Neuroinflammation. Cytokine. Cognitive symptoms. Visuospatial processing.

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Declaration of competing interest None

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