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Review
. 2024 May:82:44-52.
doi: 10.1016/j.euroneuro.2024.02.010. Epub 2024 Mar 14.

Parvalbumin interneuron deficits in schizophrenia

Oscar Marín  1
Affiliations
Review

Parvalbumin interneuron deficits in schizophrenia

Oscar Marín. Eur Neuropsychopharmacol. 2024 May.

Abstract

Parvalbumin-expressing (PV+) interneurons represent one of the most abundant subclasses of cortical interneurons. Owing to their specific electrophysiological and synaptic properties, PV+ interneurons are essential for gating and pacing the activity of excitatory neurons. In particular, PV+ interneurons are critically involved in generating and maintaining cortical rhythms in the gamma frequency, which are essential for complex cognitive functions. Deficits in PV+ interneurons have been frequently reported in postmortem studies of schizophrenia patients, and alterations in gamma oscillations are a prominent electrophysiological feature of the disease. Here, I summarise the main features of PV+ interneurons and review clinical and preclinical studies linking the developmental dysfunction of cortical PV+ interneurons with the pathophysiology of schizophrenia.

Keywords: EEG, MEG; GABA; cerebral cortex; fast-spiking; interneuron; parvalbumin; post-mortem; schizophrenia.

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Conflict of interest statement

Conflict of Interest Statement The author has no conflict of interest to declare.

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