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. 2024 Apr;4(4):443-444.
doi: 10.1038/s43587-024-00606-2.

Hearing loss promotes Alzheimer's disease

Hong-Bo Zhao  1 , Yang Yang  2
Affiliations

Hearing loss promotes Alzheimer's disease

Hong-Bo Zhao et al. Nat Aging. 2024 Apr.

Abstract

Epidemiological studies reveal a correlation between hearing loss and the development and progression of Alzheimer’s disease (AD), but the underlying causal mechanisms remain unclear. A study now provides experimental evidence that hearing loss can promote AD via the growth differentiation factor 1 (GDF1) pathway, which may aid in developing potential AD therapeutic strategies.

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Figures

Fig. 1 ∣
Fig. 1 ∣. Hearing loss promotes AD via the GDF1-mediated AKT signaling pathway.
a, Hearing loss activates C/EBPβ and suppresses GDF1 to reduce AKT activation and promote AEP activity, which can increase Aβ production and cognitive decline. b, Targeting approaches that promote GDF1 signaling (for example, GDF1 overexpression) ameliorates AD-associated pathology and rescues cognitive decline.
See this image and copyright information in PMC

References

    1. Livingston G. et al. Lancet 390, 2673–2734 (2017). - PubMed
    1. Marinelli JP et al. Lancet Healthy Longev. 3, e817–e824 (2022). - PMC - PubMed
    1. Pan L. et al. Nat. Aging 10.1038/s43587-024-00592-5 (2024). - DOI
    1. Sinha UK, Hollen KM, Rodriguez R. & Miller CA Neurology 43, 779–785 (1993). - PubMed
    1. Liu Y. et al. Neurosci. Lett 717, 134705 (2020). - PMC - PubMed

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