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. 2024 Feb;176(4):505-508.
doi: 10.1007/s10517-024-06056-5. Epub 2024 Mar 16.

Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians

S O Lukyanova  1 , O V Artemyeva  2 , I D Strazhesko  1 , E D Nasaeva  1 , V V Grechenko  1 , L V Gankovskaya  1
Affiliations

Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians

S O Lukyanova et al. Bull Exp Biol Med. 2024 Feb.

Abstract

The expression of the gene of pattern recognition receptor TLR2, proinflammatory cytokine IL-1β, and anti-inflammatory cytokine IL-10 was analyzed in the peripheral blood of nonagenarians (n=219; mean age 92.1 years, 77 men and 142 women) in comparison with healthy young donors (n=24; mean age 22.5 years, 16 women and 8 men). Nonagenarians were interviewed, medical records were analyzed, and a comprehensive geriatric assessment was performed according to the Clinical Guidelines on Frailty. The level of gene expression was determined by real-time PCR. The participation of inflammatory mechanisms in the immunosenescence was revealed. It was shown that increased expression of IL1B and TLR2 genes is associated with the development of frailty in nonagenarians and can be a factor of pathological aging. Increased expression of IL10 gene can be considered as a factor of successful aging in nonagenarians.

Keywords: TLR; cytokines; gene expression; inflammaging; longevity.

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References

    1. Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. NY Acad. Sci. 2000;908:244-254. https://doi.org/10.1111/j.1749-6632.2000.tb06651.x
    1. Santoro A, Bientinesi E, Monti D. Immunosenescence and inflammaging in the aging process: age-related diseases or longevity? Ageing Res. Rev. 2021;71:101422. https://doi.org/10.1016/j.arr.2021.101422 - DOI - PubMed
    1. Artemyeva OV, Gankovskaya LV. Inflammaging as the basis of age-associated diseases. Med. Immunol. 2020;22(3):419-432. Russian. https://doi.org/10.15789/1563-0625-IAT-1938
    1. Fulop T, Witkowski JM, Olivieri F, Larbi A. The integration of inflammaging in age-related diseases. Semin. Immunol. 2018;40:17-35. https://doi.org/10.1016/j.smim.2018.09.003 - DOI - PubMed
    1. Vetrano DL, Palmer K, Marengoni A, Marzetti E, Lattanzio F, Roller-Wirnsberger R, Lopez Samaniego L, Rodríguez-Mañas L, Bernabei R, Onder G; Joint Action ADVANTAGE WP4 Group. Frailty and Multimorbidity: A Systematic Review and Meta-analysis. J. Gerontol. A Biol. Sci. Med. Sci. 2019;74(5):659-666. https://doi.org/10.1093/gerona/gly110

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