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Review
. 2024 Sep;82(5):755-761.
doi: 10.1016/j.pharma.2024.03.004. Epub 2024 Mar 16.

Urinary cytomegalovirus excretion: The unresolved issues

Line Puget  1 , Juliette Node  1 , Blandine Caël  2 , Jamal Bamoulid  3 , Alain Coaquette  2 , Jean-Luc Prétet  4 , Quentin Lepiller  5
Affiliations
Review

Urinary cytomegalovirus excretion: The unresolved issues

Line Puget et al. Ann Pharm Fr. 2024 Sep.

Abstract

Cytomegalovirus (CMV) excretion in urine is frequently observed in clinical practice. However, the specific circumstances and pathophysiological mechanisms underlying this shedding remain largely unknown. Here, we address some of the key questions regarding urinary CMV excretion, focusing on new hypotheses raised by recent advances in the field. Cellular origins of CMV shedding, clinical contexts of occurrence, systemic spread of the virus versus compartmentalization in the urinary tract, and clinical impact are successively discussed.

Keywords: Cytomegalovirus; Cytomégalovirus; Viruria; Virurie.

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