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Review
. 2024 Mar;47(3):165-218.
doi: 10.1007/s12272-024-01489-y. Epub 2024 Mar 16.

Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application

Ya-Xiao Liu #  1 , Xiao-Mei Song #  1   2 , Lin-Wei Dan  1 , Jia-Mei Tang  1 , Yi Jiang  1   2 , Chong Deng  1   2 , Dong-Dong Zhang  1   2 , Yu-Ze Li  3   4 , Wei Wang  5   6
Affiliations
Review

Astragali Radix: comprehensive review of its botany, phytochemistry, pharmacology and clinical application

Ya-Xiao Liu et al. Arch Pharm Res. 2024 Mar.

Abstract

Astragali Radix (A. Radix) is the dried root of Astragalus membranaceus var. mongholicus (Bge) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the family Leguminosae, which is mainly distributed in China. A. Radix has been consumed as a tonic in China for more than 2000 years because of its medicinal effects of invigorating the spleen and replenishing qi. Currently, more than 400 natural compounds have been isolated and identified from A. Radix, mainly including saponins, flavonoids, phenylpropanoids, alkaloids, and others. Modern pharmacological studies have shown that A. Radix has anti-tumor, anti-inflammatory, immunomodulatory, anti-atherosclerotic, cardioprotective, anti-hypertensive, and anti-aging effects. It has been clinically used in the treatment of tumors, cardiovascular diseases, and cerebrovascular complications associated with diabetes with few side effects and high safety. This paper reviewed the progress of research on its chemical constituents, pharmacological effects, clinical applications, developing applications, and toxicology, which provides a basis for the better development and utilization of A. Radix.

Keywords: Astragali Radix (a. Radix); Chemical composition; Clinical application; Developing applications; Pharmacological effect.

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