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. 2024 May;34(5):352-354.
doi: 10.1016/j.tcb.2024.03.001. Epub 2024 Mar 16.

Crosstalk between TPC2 and IP3R regulates Ca2+ signals

Christina Humer  1 , Rainer Schindl  2 , Matthias Sallinger  1
Affiliations
Free article

Crosstalk between TPC2 and IP3R regulates Ca2+ signals

Christina Humer et al. Trends Cell Biol. 2024 May.
Free article

Abstract

Calcium (Ca2+) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca2+ concentration. Intracellular organelles serve as Ca2+ stores that induce differently shaped Ca2+ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP3Rs).

Keywords: IP3R; MITF; TFEB; TPC2; lysosomal Ca(2+).

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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