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. 2024 May;35(5):911-918.
doi: 10.1007/s00198-024-07042-3. Epub 2024 Mar 18.

The yield of routine laboratory examination in osteoporosis evaluation in primary care

Thomas Merlijn  1 , Karin M A Swart  2 , Christy Niemeijer  3 , Henriëtte E van der Horst  4 , Coen J Netelenbos  5 , Petra J M Elders  6
Affiliations

The yield of routine laboratory examination in osteoporosis evaluation in primary care

Thomas Merlijn et al. Osteoporos Int. 2024 May.

Abstract

This study evaluated the yield of routine laboratory examination in a large population of older women in primary care. The prevalence of laboratory abnormalities was low and the clinical consequences in follow-up were limited. There was a weak association of laboratory abnormalities with osteoporosis but no association with vertebral fractures and recent fractures.

Purpose: Most osteoporosis guidelines advice routine laboratory examination. We have investigated the yield of laboratory examinations in facture risk evaluation of elderly women in primary care.

Methods: We assessed the prevalence of laboratory abnormalities and their association with risk factors for fractures, recent fractures, low bone mineral density (BMD), and prevalent vertebral fracture in 8996 women ≥ 65 years of age participating in a primary care fracture risk screening study. In a sample of 2208 of these participants, we also evaluated the medical consequences in the medical records during a follow-up period of ≥ 1 year.

Results: Vitamin D deficiency (< 30 nmol/L) was present in 13% and insufficiency (< 50 nmol/L) in 43% of the study sample. The prevalence of other laboratory abnormalities (ESR, calcium, creatinine, FT4) was 4.6% in women with risk factors for fractures, 6.1% in women with low BMD (T-score ≤ - 2.5), 6.0% after a prevalent vertebral fracture, 5.2% after a recent fracture and 2.6% in the absence of important risk factors for fractures. Laboratory abnormalities other than vitamin D were associated with low BMD (OR 1.4, 95%CI 1.1-1.8) but not with prevalent vertebral fractures nor recent fractures. Low BMD was associated with renal failure (OR 2.0, 95%CI 1.3-3.4), vitamin D insufficiency (OR 1.2, 95%CI 1.0-1.3) and deficiency (OR 1.3, 95%CI 1.1-.5). In the follow-up period, 82% of the laboratory abnormalities did not result in a new diagnosis or treatment reported in the medical records.

Conclusions: We identified a low prevalence of laboratory abnormalities in a primary care population of older women and the majority of these findings had no medical consequences.

Keywords: Bone density; Clinical chemistry tests; Fractures; Osteoporosis; Primary health care; Vitamin D deficiency.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Flow diagram of evaluation of the medical file at least one year after routine laboratory examination
See this image and copyright information in PMC

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