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Editorial
. 2024 Feb 29;13(2):236-239.
doi: 10.21037/tlcr-23-705. Epub 2024 Feb 20.

High-resolution genomic configuration of FGFR rearrangements dictates the therapeutic vulnerability of squamous cell lung cancers

Sook-Hee Hong  1   2 , Tae-Min Kim  2   3   4
Affiliations
Editorial

High-resolution genomic configuration of FGFR rearrangements dictates the therapeutic vulnerability of squamous cell lung cancers

Sook-Hee Hong et al. Transl Lung Cancer Res. .
No abstract available

Keywords: FGFR1 amplification; FGFR1 dependency; Sequencing; squamous cell lung cancer (SQCLC).

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-23-705/coif). The authors have no conflicts of interest to declare.

Comment on

  • Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer.
    Malchers F, Nogova L, van Attekum MH, Maas L, Brägelmann J, Bartenhagen C, Girard L, Bosco G, Dahmen I, Michels S, Weeden CE, Scheel AH, Meder L, Golfmann K, Schuldt P, Siemanowski J, Rehker J, Merkelbach-Bruse S, Menon R, Gautschi O, Heuckmann JM, Brambilla E, Asselin-Labat ML, Persigehl T, Minna JD, Walczak H, Ullrich RT, Fischer M, Reinhardt HC, Wolf J, Büttner R, Peifer M, George J, Thomas RK. Malchers F, et al. J Clin Invest. 2023 Nov 1;133(21):e170217. doi: 10.1172/JCI170217. J Clin Invest. 2023. PMID: 37606995 Free PMC article.

References

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    1. Lau SCM, Pan Y, Velcheti V, et al. Squamous cell lung cancer: Current landscape and future therapeutic options. Cancer Cell 2022;40:1279-93. 10.1016/j.ccell.2022.09.018 - DOI - PubMed
    1. Novello S, Kowalski DM, Luft A, et al. Pembrolizumab Plus Chemotherapy in Squamous Non-Small-Cell Lung Cancer: 5-Year Update of the Phase III KEYNOTE-407 Study. J Clin Oncol 2023;41:1999-2006. 10.1200/JCO.22.01990 - DOI - PMC - PubMed
    1. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012;489:519-25. 10.1038/nature11404 - DOI - PMC - PubMed
    1. Wynes MW, Hinz TK, Gao D, et al. FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies. Clin Cancer Res 2014;20:3299-309. 10.1158/1078-0432.CCR-13-3060 - DOI - PMC - PubMed